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Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis.
Klint S, Feldwisch J, Gudmundsdotter L, Dillner Bergstedt K, Gunneriusson E, Höidén Guthenberg I, Wennborg A, Nyborg AC, Kamboj AP, Peloso PM, Bejker D, Frejd FY. Klint S, et al. Among authors: hoiden guthenberg i. MAbs. 2023 Jan-Dec;15(1):2209920. doi: 10.1080/19420862.2023.2209920. MAbs. 2023. PMID: 37184136 Free PMC article.
Affibody-Mediated Sequestration of Amyloid β Demonstrates Preventive Efficacy in a Transgenic Alzheimer's Disease Mouse Model.
Boutajangout A, Lindberg H, Awwad A, Paul A, Baitalmal R, Almokyad I, Höidén-Guthenberg I, Gunneriusson E, Frejd FY, Härd T, Löfblom J, Ståhl S, Wisniewski T. Boutajangout A, et al. Among authors: hoiden guthenberg i. Front Aging Neurosci. 2019 Mar 22;11:64. doi: 10.3389/fnagi.2019.00064. eCollection 2019. Front Aging Neurosci. 2019. PMID: 30967771 Free PMC article.
Cellular effects of HER3-specific affibody molecules.
Göstring L, Malm M, Höidén-Guthenberg I, Frejd FY, Ståhl S, Löfblom J, Gedda L. Göstring L, et al. Among authors: hoiden guthenberg i. PLoS One. 2012;7(6):e40023. doi: 10.1371/journal.pone.0040023. Epub 2012 Jun 29. PLoS One. 2012. PMID: 22768204 Free PMC article.
An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein.
Seijsing J, Lindborg M, Höidén-Guthenberg I, Bönisch H, Guneriusson E, Frejd FY, Abrahmsén L, Ekblad C, Löfblom J, Uhlén M, Gräslund T. Seijsing J, et al. Among authors: hoiden guthenberg i. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17110-5. doi: 10.1073/pnas.1417717111. Epub 2014 Nov 18. Proc Natl Acad Sci U S A. 2014. PMID: 25406323 Free PMC article.
Design of an optimized scaffold for affibody molecules.
Feldwisch J, Tolmachev V, Lendel C, Herne N, Sjöberg A, Larsson B, Rosik D, Lindqvist E, Fant G, Höidén-Guthenberg I, Galli J, Jonasson P, Abrahmsén L. Feldwisch J, et al. Among authors: hoiden guthenberg i. J Mol Biol. 2010 Apr 30;398(2):232-47. doi: 10.1016/j.jmb.2010.03.002. Epub 2010 Mar 10. J Mol Biol. 2010. PMID: 20226194
Inhibiting HER3-mediated tumor cell growth with affibody molecules engineered to low picomolar affinity by position-directed error-prone PCR-like diversification.
Malm M, Kronqvist N, Lindberg H, Gudmundsdotter L, Bass T, Frejd FY, Höidén-Guthenberg I, Varasteh Z, Orlova A, Tolmachev V, Ståhl S, Löfblom J. Malm M, et al. Among authors: hoiden guthenberg i. PLoS One. 2013 May 10;8(5):e62791. doi: 10.1371/journal.pone.0062791. Print 2013. PLoS One. 2013. PMID: 23675426 Free PMC article.
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