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Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance.
Nat Commun. 2023 Aug 29;14(1):5253. doi: 10.1038/s41467-023-40760-6.
Nat Commun. 2023.
PMID: 37644036
Free PMC article.
PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis.
Jayappa KD, Tran B, Gordon VL, Morris C, Saha S, Farrington CC, O'Connor CM, Zawacki KP, Isaac KM, Kester M, Bender TP, Williams ME, Portell CA, Weber MJ, Narla G.
Jayappa KD, et al. Among authors: zawacki kp.
J Clin Invest. 2023 Jul 3;133(13):e155938. doi: 10.1172/JCI155938.
J Clin Invest. 2023.
PMID: 37166997
Free PMC article.
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Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma.
O'Connor CM, Taylor SE, Miller KM, Hurst L, Haanen TJ, Suhan TK, Zawacki KP, Noto FK, Trako J, Mohan A, Sangodkar J, Zamarin D, DiFeo A, Narla G.
O'Connor CM, et al. Among authors: zawacki kp.
Cancer Res. 2022 Feb 15;82(4):721-733. doi: 10.1158/0008-5472.CAN-21-1987.
Cancer Res. 2022.
PMID: 34921012
Free PMC article.
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Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.
Rej RK, Wang C, Lu J, Wang M, Petrunak E, Zawacki KP, McEachern D, Yang CY, Wang L, Li R, Chinnaswamy K, Wen B, Sun D, Stuckey JA, Zhou Y, Chen J, Tang G, Wang S.
Rej RK, et al. Among authors: zawacki kp.
J Med Chem. 2021 Oct 14;64(19):14540-14556. doi: 10.1021/acs.jmedchem.1c01059. Epub 2021 Oct 6.
J Med Chem. 2021.
PMID: 34613724
Free PMC article.
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EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development.
Rej RK, Wang C, Lu J, Wang M, Petrunak E, Zawacki KP, McEachern D, Fernandez-Salas E, Yang CY, Wang L, Li R, Chinnaswamy K, Wen B, Sun D, Stuckey J, Zhou Y, Chen J, Tang G, Wang S.
Rej RK, et al. Among authors: zawacki kp.
J Med Chem. 2020 Jul 9;63(13):7252-7267. doi: 10.1021/acs.jmedchem.0c00479. Epub 2020 Jun 24.
J Med Chem. 2020.
PMID: 32580550
Free PMC article.
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