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Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall.
Raju S, Botts SR, Blaser M, Prajapati K, Ho TWW, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL. Raju S, et al. Among authors: lee wl. bioRxiv [Preprint]. 2023 Apr 29:2023.04.28.538787. doi: 10.1101/2023.04.28.538787. bioRxiv. 2023. PMID: 37162986 Free PMC article. Preprint.
The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice.
Petruzziello-Pellegrini TN, Yuen DA, Page AV, Patel S, Soltyk AM, Matouk CC, Wong DK, Turgeon PJ, Fish JE, Ho JJ, Steer BM, Khajoee V, Tigdi J, Lee WL, Motto DG, Advani A, Gilbert RE, Karumanchi SA, Robinson LA, Tarr PI, Liles WC, Brunton JL, Marsden PA. Petruzziello-Pellegrini TN, et al. Among authors: lee wl. J Clin Invest. 2012 Feb;122(2):759-76. doi: 10.1172/JCI57313. Epub 2012 Jan 9. J Clin Invest. 2012. PMID: 22232208 Free PMC article.
The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus.
Bhosle VK, Sun C, Patel S, Ho TWW, Westman J, Ammendolia DA, Langari FM, Fine N, Toepfner N, Li Z, Sharma M, Glogauer J, Capurro MI, Jones NL, Maynes JT, Lee WL, Glogauer M, Grinstein S, Robinson LA. Bhosle VK, et al. Among authors: lee wl. Elife. 2023 Sep 29;12:e87392. doi: 10.7554/eLife.87392. Elife. 2023. PMID: 37773612 Free PMC article.
Directional Endothelial Communication by Polarized Extracellular Vesicle Release.
Raju S, Botts SR, Blaser MC, Abdul-Samad M, Prajapati K, Khosraviani N, Ho TWW, Breda LCD, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL. Raju S, et al. Among authors: lee wl. Circ Res. 2024 Feb 2;134(3):269-289. doi: 10.1161/CIRCRESAHA.123.322993. Epub 2024 Jan 4. Circ Res. 2024. PMID: 38174557 Free PMC article.
Circulating small extracellular vesicles mediate vascular hyperpermeability in diabetes.
Gustafson D, DiStefano PV, Wang XF, Wu R, Ghaffari S, Ching C, Rathnakumar K, Alibhai F, Syonov M, Fitzpatrick J, Boudreau E, Lau C, Galant N, Husain M, Li RK, Lee WL, Parekh RS, Monnier PP, Fish JE. Gustafson D, et al. Among authors: lee wl. Diabetologia. 2024 Jun;67(6):1138-1154. doi: 10.1007/s00125-024-06120-9. Epub 2024 Mar 15. Diabetologia. 2024. PMID: 38489029 Free PMC article.
894 results