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Endothelial cells secrete small extracellular vesicles bidirectionally containing distinct cargo to uniquely reprogram vascular cells in the circulation and vessel wall.
Raju S, Botts SR, Blaser M, Prajapati K, Ho TWW, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL. Raju S, et al. Among authors: galant nj. bioRxiv [Preprint]. 2023 Apr 29:2023.04.28.538787. doi: 10.1101/2023.04.28.538787. bioRxiv. 2023. PMID: 37162986 Free PMC article. Preprint.
Directional Endothelial Communication by Polarized Extracellular Vesicle Release.
Raju S, Botts SR, Blaser MC, Abdul-Samad M, Prajapati K, Khosraviani N, Ho TWW, Breda LCD, Ching C, Galant NJ, Fiddes L, Wu R, Clift CL, Pham T, Lee WL, Singh SA, Aikawa E, Fish JE, Howe KL. Raju S, et al. Among authors: galant nj. Circ Res. 2024 Feb 2;134(3):269-289. doi: 10.1161/CIRCRESAHA.123.322993. Epub 2024 Jan 4. Circ Res. 2024. PMID: 38174557 Free PMC article.
Circulating small extracellular vesicles mediate vascular hyperpermeability in diabetes.
Gustafson D, DiStefano PV, Wang XF, Wu R, Ghaffari S, Ching C, Rathnakumar K, Alibhai F, Syonov M, Fitzpatrick J, Boudreau E, Lau C, Galant N, Husain M, Li RK, Lee WL, Parekh RS, Monnier PP, Fish JE. Gustafson D, et al. Diabetologia. 2024 Jun;67(6):1138-1154. doi: 10.1007/s00125-024-06120-9. Epub 2024 Mar 15. Diabetologia. 2024. PMID: 38489029 Free PMC article.
MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes.
Veitch S, Njock MS, Chandy M, Siraj MA, Chi L, Mak H, Yu K, Rathnakumar K, Perez-Romero CA, Chen Z, Alibhai FJ, Gustafson D, Raju S, Wu R, Zarrin Khat D, Wang Y, Caballero A, Meagher P, Lau E, Pepic L, Cheng HS, Galant NJ, Howe KL, Li RK, Connelly KA, Husain M, Delgado-Olguin P, Fish JE. Veitch S, et al. Among authors: galant nj. Cardiovasc Diabetol. 2022 Feb 24;21(1):31. doi: 10.1186/s12933-022-01458-z. Cardiovasc Diabetol. 2022. PMID: 35209901 Free PMC article.
Canadian Cardiovascular Society/Canadian Heart Failure Society Joint Position Statement on the Evaluation and Management of Patients With Cardiac Amyloidosis.
Fine NM, Davis MK, Anderson K, Delgado DH, Giraldeau G, Kitchlu A, Massie R, Narayan J, Swiggum E, Venner CP, Ducharme A, Galant NJ, Hahn C, Howlett JG, Mielniczuk L, Parent MC, Reece D, Royal V, Toma M, Virani SA, Zieroth S. Fine NM, et al. Among authors: galant nj. Can J Cardiol. 2020 Mar;36(3):322-334. doi: 10.1016/j.cjca.2019.12.034. Can J Cardiol. 2020. PMID: 32145862
Corrigendum: Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses.
Galant NJ, Bugyei-Twum A, Rakhit R, Walsh P, Sharpe S, Arslan PE, Westermark P, Higaki JN, Torres R, Tapia J, Chakrabartty A. Galant NJ, et al. Sci Rep. 2016 Jun 10;6:27679. doi: 10.1038/srep27679. Sci Rep. 2016. PMID: 27282221 Free PMC article. No abstract available.
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