Birk B - Search Results

1

A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity.

Ramirez-Hincapie S, Birk B, Ternes P, Giri V, Haake V, Herold M, Zickgraf FM, Verlohner A, Huener HA, Kamp H, Driemert P, Landsiedel R, Richling E, Funk-Weyer D, van Ravenzwaay B. Ramirez-Hincapie S, et al. Among authors: birk b. Cell Biol Toxicol. 2023 Dec;39(6):2899-2917. doi: 10.1007/s10565-023-09809-6. Epub 2023 May 4. Cell Biol Toxicol. 2023. PMID: 37138123 Free PMC article.

2

Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.

Heim R, Lucas S, Grombein CM, Ries C, Schewe KE, Negri M, Müller-Vieira U, Birk B, Hartmann RW. Heim R, et al. Among authors: birk b. J Med Chem. 2008 Aug 28;51(16):5064-74. doi: 10.1021/jm800377h. Epub 2008 Aug 1. J Med Chem. 2008. PMID: 18672861

3

In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.

Lucas S, Heim R, Ries C, Schewe KE, Birk B, Hartmann RW. Lucas S, et al. Among authors: birk b. J Med Chem. 2008 Dec 25;51(24):8077-87. doi: 10.1021/jm800888q. J Med Chem. 2008. PMID: 19049427

4

Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1).

Bey E, Marchais-Oberwinkler S, Werth R, Negri M, Al-Soud YA, Kruchten P, Oster A, Frotscher M, Birk B, Hartmann RW. Bey E, et al. Among authors: birk b. J Med Chem. 2008 Nov 13;51(21):6725-39. doi: 10.1021/jm8006917. Epub 2008 Oct 15. J Med Chem. 2008. PMID: 18855374

5

Investigation of ruminant xenobiotic metabolism in a modified rumen simulation system (RUSITEC).

Birk B, Stähle A, Meier M, Palm M, Funk-Weyer D, Breves G, Seulberger H. Birk B, et al. ALTEX. 2018;35(3):379-389. doi: 10.14573/altex.1712221. Epub 2018 Mar 12. ALTEX. 2018. PMID: 29536108 Free article.

6

In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds.

Fabian E, Gomes C, Birk B, Williford T, Hernandez TR, Haase C, Zbranek R, van Ravenzwaay B, Landsiedel R. Fabian E, et al. Among authors: birk b. Arch Toxicol. 2019 Feb;93(2):401-416. doi: 10.1007/s00204-018-2372-z. Epub 2018 Dec 14. Arch Toxicol. 2019. PMID: 30552464

7

The kinetic direct peptide reactivity assay (kDPRA): Intra- and inter-laboratory reproducibility in a seven-laboratory ring trial.

Wareing B, Kolle SN, Birk B, Alépée N, Haupt T, Kathawala R, Kern PS, Nardelli L, Raabe H, Rucki M, Ryan CA, Verkaart S, Westerink WMA, Landsiedel R, Natsch A. Wareing B, et al. Among authors: birk b. ALTEX. 2020;37(4):639-651. doi: 10.14573/altex.2004291. Epub 2020 Jun 10. ALTEX. 2020. PMID: 32521036 Free article.

8

In Silico Models to Predict the Perturbation of Molecular Initiating Events Related to Thyroid Hormone Homeostasis.

Garcia de Lomana M, Weber AG, Birk B, Landsiedel R, Achenbach J, Schleifer KJ, Mathea M, Kirchmair J. Garcia de Lomana M, et al. Among authors: birk b. Chem Res Toxicol. 2021 Feb 15;34(2):396-411. doi: 10.1021/acs.chemrestox.0c00304. Epub 2020 Nov 13. Chem Res Toxicol. 2021. PMID: 33185102 Free PMC article.

9

Use of in vitro metabolomics in NRK cells to help predicting nephrotoxicity and differentiating the MoA of nephrotoxicants.

Birk B, Haake V, Sperber S, Herold M, Wallisch SK, Huener HA, Verlohner A, Amma MM, Walk T, Hernandez TR, Hewitt NJ, Kamp H, van Ravenzwaay B. Birk B, et al. Toxicol Lett. 2021 Dec 15;353:43-59. doi: 10.1016/j.toxlet.2021.09.011. Epub 2021 Oct 6. Toxicol Lett. 2021. PMID: 34626816

10

The thyroid hormone converting enzyme human deiodinase 1 is inhibited by gold ions from inorganic salts, organic substances, and by small-size nanoparticles.

Weber AG, Birk B, Müller C, Schneider S, van Ravenzwaay B, Funk-Weyer D, Landsiedel R. Weber AG, et al. Among authors: birk b. Chem Biol Interact. 2022 Jan 5;351:109709. doi: 10.1016/j.cbi.2021.109709. Epub 2021 Oct 16. Chem Biol Interact. 2022. PMID: 34662569

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