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High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained.
Bryce NS, Failes TW, Stehn JR, Baker K, Zahler S, Arzhaeva Y, Bischof L, Lyons C, Dedova I, Arndt GM, Gaus K, Goult BT, Hardeman EC, Gunning PW, Lock JG. Bryce NS, et al. Among authors: stehn jr. Cell Syst. 2019 Nov 27;9(5):496-507.e5. doi: 10.1016/j.cels.2019.09.002. Epub 2019 Oct 9. Cell Syst. 2019. PMID: 31606369 Free article.
On-target action of anti-tropomyosin drugs regulates glucose metabolism.
Kee AJ, Chagan J, Chan JY, Bryce NS, Lucas CA, Zeng J, Hook J, Treutlein H, Laybutt DR, Stehn JR, Gunning PW, Hardeman EC. Kee AJ, et al. Among authors: stehn jr. Sci Rep. 2018 Mar 15;8(1):4604. doi: 10.1038/s41598-018-22946-x. Sci Rep. 2018. PMID: 29545590 Free PMC article.
Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs.
Currier MA, Stehn JR, Swain A, Chen D, Hook J, Eiffe E, Heaton A, Brown D, Nartker BA, Eaves DW, Kloss N, Treutlein H, Zeng J, Alieva IB, Dugina VB, Hardeman EC, Gunning PW, Cripe TP. Currier MA, et al. Among authors: stehn jr. Mol Cancer Ther. 2017 Aug;16(8):1555-1565. doi: 10.1158/1535-7163.MCT-16-0873. Epub 2017 May 18. Mol Cancer Ther. 2017. PMID: 28522589
Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments.
Schevzov G, Kee AJ, Wang B, Sequeira VB, Hook J, Coombes JD, Lucas CA, Stehn JR, Musgrove EA, Cretu A, Assoian R, Fath T, Hanoch T, Seger R, Pleines I, Kile BT, Hardeman EC, Gunning PW. Schevzov G, et al. Among authors: stehn jr. Mol Biol Cell. 2015 Jul 1;26(13):2475-90. doi: 10.1091/mbc.E14-10-1453. Epub 2015 May 13. Mol Biol Cell. 2015. PMID: 25971798 Free PMC article.
16 results