Lee DY - Search Results

1

Data-driven prediction models for forecasting multistep ahead profiles of mammalian cell culture toward bioprocess digital twins.

Park SY, Kim SJ, Park CH, Kim J, Lee DY. Park SY, et al. Among authors: lee dy. Biotechnol Bioeng. 2023 Sep;120(9):2494-2508. doi: 10.1002/bit.28405. Epub 2023 Apr 20. Biotechnol Bioeng. 2023. PMID: 37079452

2

Elucidation of metabolism in hybridoma cells grown in fed-batch culture by genome-scale modeling.

Selvarasu S, Wong VV, Karimi IA, Lee DY. Selvarasu S, et al. Among authors: lee dy. Biotechnol Bioeng. 2009 Apr 1;102(5):1494-504. doi: 10.1002/bit.22186. Biotechnol Bioeng. 2009. PMID: 19048615

3

Quantitative intracellular flux modeling and applications in biotherapeutic development and production using CHO cell cultures.

Huang Z, Lee DY, Yoon S. Huang Z, et al. Among authors: lee dy. Biotechnol Bioeng. 2017 Dec;114(12):2717-2728. doi: 10.1002/bit.26384. Epub 2017 Sep 11. Biotechnol Bioeng. 2017. PMID: 28710856 Review.

4

Multi-omics profiling of CHO parental hosts reveals cell line-specific variations in bioprocessing traits.

Lakshmanan M, Kok YJ, Lee AP, Kyriakopoulos S, Lim HL, Teo G, Poh SL, Tang WQ, Hong J, Tan AH, Bi X, Ho YS, Zhang P, Ng SK, Lee DY. Lakshmanan M, et al. Among authors: lee dy, lee ap. Biotechnol Bioeng. 2019 Sep;116(9):2117-2129. doi: 10.1002/bit.27014. Epub 2019 May 20. Biotechnol Bioeng. 2019. PMID: 31066037

5

Multi-omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and product quality.

Lee AP, Kok YJ, Lakshmanan M, Leong D, Zheng L, Lim HL, Chen S, Mak SY, Ang KS, Templeton N, Salim T, Wei X, Gifford E, Tan AH, Bi X, Ng SK, Lee DY, Ling WLW, Ho YS. Lee AP, et al. Among authors: lee dy. Biotechnol Bioeng. 2021 Nov;118(11):4305-4316. doi: 10.1002/bit.27899. Epub 2021 Jul 31. Biotechnol Bioeng. 2021. PMID: 34289087

6

Combined multivariate statistical and flux balance analyses uncover media bottlenecks to the growth and productivity of Chinese hamster ovary cell cultures.

Yeo HC, Park SY, Tan T, Ng SK, Lakshmanan M, Lee DY. Yeo HC, et al. Among authors: lee dy. Biotechnol Bioeng. 2022 Jul;119(7):1740-1754. doi: 10.1002/bit.28104. Epub 2022 Apr 25. Biotechnol Bioeng. 2022. PMID: 35435243

7

Data-driven and model-guided systematic framework for media development in CHO cell culture.

Hong JK, Choi DH, Park SY, Silberberg YR, Shozui F, Nakamura E, Kayahara T, Lee DY. Hong JK, et al. Among authors: lee dy. Metab Eng. 2022 Sep;73:114-123. doi: 10.1016/j.ymben.2022.07.003. Epub 2022 Jul 4. Metab Eng. 2022. PMID: 35798249

8

Debottlenecking and reformulating feed media for improved CHO cell growth and titer by data-driven and model-guided analyses.

Park SY, Choi DH, Song J, Park U, Cho H, Hong BH, Silberberg YR, Lee DY. Park SY, et al. Among authors: lee dy. Biotechnol J. 2023 Dec;18(12):e2300126. doi: 10.1002/biot.202300126. Epub 2023 Aug 27. Biotechnol J. 2023. PMID: 37605365

9

Exploring metabolic effects of dipeptide feed media on CHO cell cultures by in silico model-guided flux analysis.

Park SY, Song J, Choi DH, Park U, Cho H, Hong BH, Silberberg YR, Lee DY. Park SY, et al. Among authors: lee dy. Appl Microbiol Biotechnol. 2024 Dec;108(1):123. doi: 10.1007/s00253-023-12997-0. Epub 2024 Jan 16. Appl Microbiol Biotechnol. 2024. PMID: 38229404 Free PMC article.

10

Driving towards digital biomanufacturing by CHO genome-scale models.

Park SY, Choi DH, Song J, Lakshmanan M, Richelle A, Yoon S, Kontoravdi C, Lewis NE, Lee DY. Park SY, et al. Among authors: lee dy. Trends Biotechnol. 2024 Mar 27:S0167-7799(24)00065-9. doi: 10.1016/j.tibtech.2024.03.001. Online ahead of print. Trends Biotechnol. 2024. PMID: 38548556 Review.

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