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Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy.
Talebi A, de Laat V, Spotbeen X, Dehairs J, Rambow F, Rogiers A, Vanderhoydonc F, Rizotto L, Planque M, Doglioni G, Motamedi S, Nittner D, Roskams T, Agostinis P, Bechter O, Boecxstaens V, Garmyn M, O'Farrell M, Wagman A, Kemble G, Leucci E, Fendt SM, Marine JC, Swinnen JV. Talebi A, et al. Among authors: fendt sm. J Exp Clin Cancer Res. 2023 Apr 19;42(1):92. doi: 10.1186/s13046-023-02664-7. J Exp Clin Cancer Res. 2023. PMID: 37072838 Free PMC article.
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.
Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis J. Csibi A, et al. Among authors: fendt sm. Cell. 2021 Apr 15;184(8):2256. doi: 10.1016/j.cell.2021.03.059. Cell. 2021. PMID: 33861966 Free article. No abstract available.
(13)C-based metabolic flux analysis.
Zamboni N, Fendt SM, Rühl M, Sauer U. Zamboni N, et al. Among authors: fendt sm. Nat Protoc. 2009;4(6):878-92. doi: 10.1038/nprot.2009.58. Epub 2009 May 21. Nat Protoc. 2009. PMID: 19478804
117 results