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Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice.
Dorfman MD, Monfeuga T, Melhorn SJ, Kanter JE, Frey JM, Fasnacht RD, Chandran A, Lala E, Velasco I, Rubinow KB, Meek TH, Schur EA, Bornfeldt KE, Thaler JP. Dorfman MD, et al. Among authors: thaler jp. Am J Physiol Endocrinol Metab. 2023 May 1;324(5):E461-E475. doi: 10.1152/ajpendo.00059.2023. Epub 2023 Apr 13. Am J Physiol Endocrinol Metab. 2023. PMID: 37053049 Free PMC article.
Obesity is associated with hypothalamic injury in rodents and humans.
Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, Horvath TL, Baskin DG, Tschöp MH, Schwartz MW. Thaler JP, et al. J Clin Invest. 2012 Jan;122(1):153-62. doi: 10.1172/JCI59660. Epub 2011 Dec 27. J Clin Invest. 2012. PMID: 22201683 Free PMC article.
In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue.
Matsen ME, Thaler JP, Wisse BE, Guyenet SJ, Meek TH, Ogimoto K, Cubelo A, Fischer JD, Kaiyala KJ, Schwartz MW, Morton GJ. Matsen ME, et al. Among authors: thaler jp. Am J Physiol Endocrinol Metab. 2013 Apr 1;304(7):E734-46. doi: 10.1152/ajpendo.00488.2012. Epub 2013 Feb 5. Am J Physiol Endocrinol Metab. 2013. PMID: 23384771 Free PMC article.
37 results