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Page 1
Model-informed approach to support pediatric dosing for the pan-PI3K inhibitor copanlisib in children and adolescents with relapsed/refractory solid tumors.
Morcos PN, Schlender J, Burghaus R, Moss J, Lloyd A, Childs BH, Macy ME, Reid JM, Chung J, Garmann D. Morcos PN, et al. Among authors: childs bh. Clin Transl Sci. 2023 Jul;16(7):1197-1209. doi: 10.1111/cts.13523. Epub 2023 Apr 18. Clin Transl Sci. 2023. PMID: 37042099 Free PMC article. Clinical Trial.
Copanlisib population pharmacokinetics from phase I-III studies and exposure-response relationships in combination with rituximab.
Morcos PN, Moss J, Austin R, Hiemeyer F, Zinzani PL, Beckert V, Mongay Soler L, Childs BH, Garmann D. Morcos PN, et al. Among authors: childs bh. CPT Pharmacometrics Syst Pharmacol. 2023 Nov;12(11):1666-1686. doi: 10.1002/psp4.13000. Epub 2023 Jun 30. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37389853 Free PMC article.
Correction: Single-agent activity of phosphatidylinositol 3-kinase inhibition with copanlisib in patients with molecularly defined relapsed or refractory diffuse large B-cell lymphoma.
Lenz G, Hawkes E, Verhoef G, Haioun C, Thye Lim S, Seog Heo D, Ardeshna K, Chong G, Haaber J, Shi W, Gorbatchevsky I, Lippert S, Hiemeyer F, Piraino P, Beckmann G, Peña C, Buvaylo V, Childs BH, Salles G. Lenz G, et al. Among authors: childs bh. Leukemia. 2024 Feb;38(2):469-472. doi: 10.1038/s41375-023-02133-2. Leukemia. 2024. PMID: 38200221 Free PMC article. No abstract available.
Safety and activity of anti-mesothelin antibody-drug conjugate anetumab ravtansine in combination with pegylated-liposomal doxorubicin in platinum-resistant ovarian cancer: multicenter, phase Ib dose escalation and expansion study.
Santin AD, Vergote I, González-Martín A, Moore K, Oaknin A, Romero I, Diab S, Copeland LJ, Monk BJ, Coleman RL, Herzog TJ, Siegel J, Kasten L, Schlicker A, Schulz A, Köchert K, Walter AO, Childs BH, Elbi C, Bulat I. Santin AD, et al. Among authors: childs bh. Int J Gynecol Cancer. 2023 Apr 3;33(4):562-570. doi: 10.1136/ijgc-2022-003927. Int J Gynecol Cancer. 2023. PMID: 36564099 Free PMC article. Clinical Trial.
Safety and antitumor activity of copanlisib in Japanese patients with relapsed/refractory indolent non-Hodgkin lymphoma: a phase Ib/II study.
Fukuhara N, Maruyama D, Hatake K, Nagai H, Makita S, Kamezaki K, Uchida T, Kusumoto S, Kuroda J, Iriyama C, Yanada M, Tsukamoto N, Suehiro Y, Minami H, Garcia-Vargas J, Childs BH, Yasuda M, Masuda S, Tsujino T, Terao Y, Tobinai K. Fukuhara N, et al. Among authors: childs bh. Int J Hematol. 2023 Jan;117(1):100-109. doi: 10.1007/s12185-022-03455-0. Epub 2022 Sep 29. Int J Hematol. 2023. PMID: 36175779 Free PMC article. Clinical Trial.
PI3K inhibitors in haematological malignancies.
Matasar MJ, Hiemeyer F, Childs BH, Zinzani PL. Matasar MJ, et al. Among authors: childs bh. Lancet Oncol. 2022 Aug;23(8):e365. doi: 10.1016/S1470-2045(22)00332-1. Lancet Oncol. 2022. PMID: 35901826 No abstract available.
Anetumab ravtansine versus vinorelbine in patients with relapsed, mesothelin-positive malignant pleural mesothelioma (ARCS-M): a randomised, open-label phase 2 trial.
Kindler HL, Novello S, Bearz A, Ceresoli GL, Aerts JGJV, Spicer J, Taylor P, Nackaerts K, Greystoke A, Jennens R, Calabrò L, Burgers JA, Santoro A, Cedrés S, Serwatowski P, Ponce S, Van Meerbeeck JP, Nowak AK, Blumenschein G Jr, Siegel JM, Kasten L, Köchert K, Walter AO, Childs BH, Elbi C, Hassan R, Fennell DA. Kindler HL, et al. Among authors: childs bh. Lancet Oncol. 2022 Apr;23(4):540-552. doi: 10.1016/S1470-2045(22)00061-4. Lancet Oncol. 2022. PMID: 35358455 Free PMC article. Clinical Trial.
Feasibility of Combining the Phosphatidylinositol 3-Kinase Inhibitor Copanlisib With Rituximab-Based Immunochemotherapy in Patients With Relapsed Indolent B-cell Lymphoma.
Matasar MJ, Dreyling M, Leppä S, Santoro A, Pedersen M, Buvaylo V, Fletcher M, Childs BH, Zinzani PL. Matasar MJ, et al. Among authors: childs bh. Clin Lymphoma Myeloma Leuk. 2021 Nov;21(11):e886-e894. doi: 10.1016/j.clml.2021.06.021. Epub 2021 Jul 2. Clin Lymphoma Myeloma Leuk. 2021. PMID: 34389273 Free PMC article. Clinical Trial.
65 results