SAMHD1 acetylation enhances its deoxynucleotide triphosphohydrolase activity and promotes cancer cell proliferation.
Lee EJ, Seo JH, Park JH, Vo TTL, An S, Bae SJ, Le H, Lee HS, Wee HJ, Lee D, Chung YH, Kim JA, Jang MK, Ryu SH, Yu E, Jang SH, Park ZY, Kim KW.
Lee EJ, et al. Among authors: an s.
Oncotarget. 2017 Jul 31;8(40):68517-68529. doi: 10.18632/oncotarget.19704. eCollection 2017 Sep 15.
Oncotarget. 2017.
PMID: 28978134
Free PMC article.
SAMHD1 is acetylated at residue lysine 405 (K405) in vitro and in vivo by an acetylatransferase, arrest defective protein 1 (ARD1). Acetylated SAMHD1 wildtype proteins have enhanced dNTPase activity in vitro, whereas non-acetylated arginine substituted mutants (K405R) do n …
SAMHD1 is acetylated at residue lysine 405 (K405) in vitro and in vivo by an acetylatransferase, arrest defective protein 1 (ARD1). A …