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High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases.
Xiao S, Guo S, Han J, Sun Y, Wang M, Chen Y, Fang X, Yang F, Mu Y, Zhang L, Ding Y, Zhang N, Jiang H, Chen K, Zhao K, Luo C, Chen S. Xiao S, et al. Among authors: guo s. Nucleic Acids Res. 2022 Jan 25;50(2):e9. doi: 10.1093/nar/gkab989. Nucleic Acids Res. 2022. PMID: 34718755 Free PMC article.
Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with "short" and "long" inverse agonists.
Yu MC, Yang F, Ding XY, Sun NN, Jiang ZY, Huang YF, Yan YR, Zhu C, Xie Q, Chen ZF, Guo SQ, Jiang HL, Chen KX, Luo C, Luo XM, Chen SJ, Wang YH. Yu MC, et al. Acta Pharmacol Sin. 2021 Sep;42(9):1524-1534. doi: 10.1038/s41401-020-00552-w. Epub 2020 Nov 25. Acta Pharmacol Sin. 2021. PMID: 33239687 Free PMC article.
SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors.
Wang X, Chen Z, Xu J, Tang S, An N, Jiang L, Zhang Y, Zhang S, Zhang Q, Shen Y, Chen S, Lan X, Wang T, Zhai L, Cao S, Guo S, Liu Y, Bi A, Chen Y, Gai X, Duan Y, Zheng Y, Fu Y, Li Y, Yuan L, Tong L, Mo K, Wang M, Lin SH, Tan M, Luo C, Chen Y, Liu J, Zhang Q, Li L, Huang M. Wang X, et al. Among authors: guo s. Cell Res. 2022 Jul;32(7):638-658. doi: 10.1038/s41422-022-00650-w. Epub 2022 Apr 22. Cell Res. 2022. PMID: 35459936 Free PMC article.
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