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Page 1
Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation.
Cutts A, Chowdhury S, Ratkay LG, Eyers M, Young C, Namdari R, Cadieux JA, Chahal N, Grimwood M, Zhang Z, Lin S, Tietjen I, Xie Z, Robinette L, Sojo L, Waldbrook M, Hayden M, Mansour T, Pimstone S, Goldberg YP, Webb M, Cohen CJ. Cutts A, et al. Among authors: ratkay lg. J Pharmacol Exp Ther. 2023 Jul;386(1):4-14. doi: 10.1124/jpet.122.001435. Epub 2023 Mar 23. J Pharmacol Exp Ther. 2023. PMID: 36958846
Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases.
Sun S, Zhang Z, Kodumuru V, Pokrovskaia N, Fonarev J, Jia Q, Leung PY, Tran J, Ratkay LG, McLaren DG, Radomski C, Chowdhury S, Fu J, Hubbard B, Winther MD, Dales NA. Sun S, et al. Among authors: ratkay lg. Bioorg Med Chem Lett. 2014 Jan 15;24(2):520-5. doi: 10.1016/j.bmcl.2013.12.036. Epub 2013 Dec 16. Bioorg Med Chem Lett. 2014. PMID: 24374272
Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects.
Sun S, Zhang Z, Raina V, Pokrovskaia N, Hou D, Namdari R, Khakh K, Ratkay LG, McLaren DG, Mork M, Fu J, Ferreira S, Hubbard B, Winther MD, Dales N. Sun S, et al. Among authors: ratkay lg. Bioorg Med Chem Lett. 2014 Jan 15;24(2):526-31. doi: 10.1016/j.bmcl.2013.12.035. Epub 2013 Dec 16. Bioorg Med Chem Lett. 2014. PMID: 24370012
Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome.
Zhang Z, Sun S, Kodumuru V, Hou D, Liu S, Chakka N, Sviridov S, Chowdhury S, McLaren DG, Ratkay LG, Khakh K, Cheng X, Gschwend HW, Kamboj R, Fu J, Winther MD. Zhang Z, et al. Among authors: ratkay lg. J Med Chem. 2013 Jan 24;56(2):568-83. doi: 10.1021/jm301661h. Epub 2013 Jan 7. J Med Chem. 2013. PMID: 23245208
Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors.
Zhang Z, Kodumuru V, Sviridov S, Liu S, Chafeev M, Chowdhury S, Chakka N, Sun J, Gauthier SJ, Mattice M, Ratkay LG, Kwan R, Thompson J, Cutts AB, Fu J, Kamboj R, Goldberg YP, Cadieux JA. Zhang Z, et al. Among authors: ratkay lg. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5108-13. doi: 10.1016/j.bmcl.2012.05.129. Epub 2012 Jun 15. Bioorg Med Chem Lett. 2012. PMID: 22749870
21 results