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Steroid-free combination of 5-azacytidine and venetoclax for the treatment of multiple myeloma.
Flanagan L, Coughlan A, Cosgrove N, Roe A, Wang Y, Gilmore S, Drozdz I, Comerford C, Ryan J, Minihane E, Parvin S, O'Dwyer M, Quinn J, Murphy P, Furney S, Glavey S, Chonghaile TN; Leukemia Research Foundation; Science Foundation Ireland; Breakthrough Cancer Research. Flanagan L, et al. Among authors: chonghaile tn. Haematologica. 2024 Mar 21. doi: 10.3324/haematol.2023.283771. Online ahead of print. Haematologica. 2024. PMID: 38511268 Free article.
Histone Deacetylase 6 Inhibition Exploits Selective Metabolic Vulnerabilities in LKB1 Mutant, KRAS Driven NSCLC.
Zhang H, Nabel CS, Li D, O'Connor RÍ, Crosby CR, Chang SM, Hao Y, Stanley R, Sahu S, Levin DS, Chen T, Tang S, Huang HY, Meynardie M, Stephens J, Sherman F, Chafitz A, Costelloe N, Rodrigues DA, Fogarty H, Kiernan MG, Cronin F, Papadopoulos E, Ploszaj M, Weerasekara V, Deng J, Kiely P, Bardeesy N, Vander Heiden MG, Chonghaile TN, Dowling CM, Wong KK. Zhang H, et al. Among authors: chonghaile tn. J Thorac Oncol. 2023 Jul;18(7):882-895. doi: 10.1016/j.jtho.2023.03.014. Epub 2023 Mar 22. J Thorac Oncol. 2023. PMID: 36958689 Free article.
Editorial: Cell Death and Targeted Cancer Therapies.
Bagci-Onder T, Kutuk O, Chonghaile TN, Knippschild U. Bagci-Onder T, et al. Among authors: chonghaile tn. Front Cell Dev Biol. 2022 Jul 6;10:967720. doi: 10.3389/fcell.2022.967720. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35874828 Free PMC article. No abstract available.
JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia.
Bodaar K, Yamagata N, Barthe A, Landrigan J, Chonghaile TN, Burns M, Stevenson KE, Devidas M, Loh ML, Hunger SP, Wood B, Silverman LB, Teachey DT, Meijerink JP, Letai A, Gutierrez A. Bodaar K, et al. Among authors: chonghaile tn. Leukemia. 2022 Jun;36(6):1499-1507. doi: 10.1038/s41375-022-01558-5. Epub 2022 Apr 11. Leukemia. 2022. PMID: 35411095 Free PMC article.
Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer.
Dowling CM, Hollinshead KER, Di Grande A, Pritchard J, Zhang H, Dillon ET, Haley K, Papadopoulos E, Mehta AK, Bleach R, Lindner AU, Mooney B, Düssmann H, O'Connor D, Prehn JHM, Wynne K, Hemann M, Bradner JE, Kimmelman AC, Guerriero JL, Cagney G, Wong KK, Letai AG, Chonghaile TN. Dowling CM, et al. Among authors: chonghaile tn. Sci Adv. 2021 Jan 15;7(3):eabc4897. doi: 10.1126/sciadv.abc4897. Print 2021 Jan. Sci Adv. 2021. PMID: 33523897 Free PMC article.
Shining a light on metabolic vulnerabilities in non-small cell lung cancer.
Dowling CM, Zhang H, Chonghaile TN, Wong KK. Dowling CM, et al. Among authors: chonghaile tn. Biochim Biophys Acta Rev Cancer. 2021 Jan;1875(1):188462. doi: 10.1016/j.bbcan.2020.188462. Epub 2020 Oct 29. Biochim Biophys Acta Rev Cancer. 2021. PMID: 33130228 Free PMC article. Review.
PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia.
Ariës IM, Bodaar K, Karim SA, Chonghaile TN, Hinze L, Burns MA, Pfirrmann M, Degar J, Landrigan JT, Balbach S, Peirs S, Menten B, Isenhart R, Stevenson KE, Neuberg DS, Devidas M, Loh ML, Hunger SP, Teachey DT, Rabin KR, Winter SS, Dunsmore KP, Wood BL, Silverman LB, Sallan SE, Van Vlierberghe P, Orkin SH, Knoechel B, Letai AG, Gutierrez A. Ariës IM, et al. Among authors: chonghaile tn. J Exp Med. 2018 Dec 3;215(12):3094-3114. doi: 10.1084/jem.20180570. Epub 2018 Nov 7. J Exp Med. 2018. PMID: 30404791 Free PMC article.
MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.
Benito JM, Godfrey L, Kojima K, Hogdal L, Wunderlich M, Geng H, Marzo I, Harutyunyan KG, Golfman L, North P, Kerry J, Ballabio E, Chonghaile TN, Gonzalo O, Qiu Y, Jeremias I, Debose L, O'Brien E, Ma H, Zhou P, Jacamo R, Park E, Coombes KR, Zhang N, Thomas DA, O'Brien S, Kantarjian HM, Leverson JD, Kornblau SM, Andreeff M, Müschen M, Zweidler-McKay PA, Mulloy JC, Letai A, Milne TA, Konopleva M. Benito JM, et al. Among authors: chonghaile tn. Cell Rep. 2015 Dec 29;13(12):2715-27. doi: 10.1016/j.celrep.2015.12.003. Epub 2015 Dec 17. Cell Rep. 2015. PMID: 26711339 Free PMC article.
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