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Immunosuppression reduces rAAV2.5T neutralizing antibodies that limit efficacy following repeat dosing to ferret lungs.
Mol Ther Methods Clin Dev. 2023 Mar 2;29:70-80. doi: 10.1016/j.omtm.2023.02.015. eCollection 2023 Jun 8.
Mol Ther Methods Clin Dev. 2023.
PMID: 36950451
Free PMC article.
Repeat Dosing of AAV2.5T to Ferret Lungs Elicits an Antibody Response That Diminishes Transduction in an Age-Dependent Manner.
Tang Y, Yan Z, Lin S, Huntemann ED, Feng Z, Park SY, Sun X, Yuen E, Engelhardt JF.
Tang Y, et al. Among authors: huntemann ed.
Mol Ther Methods Clin Dev. 2020 Sep 16;19:186-200. doi: 10.1016/j.omtm.2020.09.008. eCollection 2020 Dec 11.
Mol Ther Methods Clin Dev. 2020.
PMID: 33209961
Free PMC article.
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