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Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18.
Patberg M, Oniani T, Disse P, Peischard S, Vinnenberg L, Zobeiri M, Romanelli MN, Epping L, Wiendl H, Meuth SG, Hundehege P, Seebohm G, Budde T, Junker A. Patberg M, et al. Among authors: seebohm g. Arch Pharm (Weinheim). 2023 Jun;356(6):e2200665. doi: 10.1002/ardp.202200665. Epub 2023 Mar 22. Arch Pharm (Weinheim). 2023. PMID: 36949271
Inner mitochondrial membrane structure and fusion dynamics are altered in senescent human iPSC-derived and primary rat cardiomyocytes.
Morris S, Molina-Riquelme I, Barrientos G, Bravo F, Aedo G, Gómez W, Lagos D, Verdejo H, Peischard S, Seebohm G, Psathaki OE, Eisner V, Busch KB. Morris S, et al. Among authors: seebohm g. Biochim Biophys Acta Bioenerg. 2023 Apr 1;1864(2):148949. doi: 10.1016/j.bbabio.2022.148949. Epub 2022 Dec 6. Biochim Biophys Acta Bioenerg. 2023. PMID: 36493857 Free article.
MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD.
Korn L, Speicher AM, Schroeter CB, Gola L, Kaehne T, Engler A, Disse P, Fernández-Orth J, Csatári J, Naumann M, Seebohm G, Meuth SG, Schöler HR, Wiendl H, Kovac S, Pawlowski M. Korn L, et al. Among authors: seebohm g. Redox Biol. 2023 Feb;59:102597. doi: 10.1016/j.redox.2022.102597. Epub 2022 Dec 30. Redox Biol. 2023. PMID: 36599286 Free PMC article.
Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination.
Kapell H, Fazio L, Dyckow J, Schwarz S, Cruz-Herranz A, Mayer C, Campos J, D'Este E, Möbius W, Cordano C, Pröbstel AK, Gharagozloo M, Zulji A, Narayanan Naik V, Delank A, Cerina M, Müntefering T, Lerma-Martin C, Sonner JK, Sin JH, Disse P, Rychlik N, Sabeur K, Chavali M, Srivastava R, Heidenreich M, Fitzgerald KC, Seebohm G, Stadelmann C, Hemmer B, Platten M, Jentsch TJ, Engelhardt M, Budde T, Nave KA, Calabresi PA, Friese MA, Green AJ, Acuna C, Rowitch DH, Meuth SG, Schirmer L. Kapell H, et al. Among authors: seebohm g. J Clin Invest. 2023 Apr 3;133(7):e164223. doi: 10.1172/JCI164223. J Clin Invest. 2023. PMID: 36719741 Free PMC article.
Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation.
Schroeter CB, Nelke C, Schewe M, Spohler L, Herrmann AM, Müntefering T, Huntemann N, Kuzikov M, Gribbon P, Albrecht S, Bock S, Hundehege P, Neelsen LC, Baukrowitz T, Seebohm G, Wünsch B, Bittner S, Ruck T, Budde T, Meuth SG. Schroeter CB, et al. Among authors: seebohm g. Biol Chem. 2023 Feb 14;404(4):355-375. doi: 10.1515/hsz-2022-0266. Print 2023 Mar 28. Biol Chem. 2023. PMID: 36774650 Free article.
Characterization of Kv1.2-mediated outward current in TRIP8b-deficient mice.
Labbaf A, Dellin M, Komadowski M, Chetkovich DM, Decher N, Pape HC, Seebohm G, Budde T, Zobeiri M. Labbaf A, et al. Among authors: seebohm g. Biol Chem. 2023 Mar 1;404(4):291-302. doi: 10.1515/hsz-2023-0116. Print 2023 Mar 28. Biol Chem. 2023. PMID: 36852869 Free article.
181 results