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Genomic analysis across 53 canine cancer types reveals novel mutations and high clinical actionability potential.
Sakthikumar S, Warrier M, Whitley D, Facista S, Adkins J, Aman S, Tsinajinnie D, Duran N, Siravegna G, Ahmed Z, Day K, Jenkins B, Patel N, Ryden K, Nadai J, Banovich K, Powers B, Edwards J, Steinberg J, Fielder S, Wong S, Byron SA, Izatt T, Zismann V, Boateng M, Zhu Z, Chuang HY, Trent JM, Haworth D, Chon E, Hendricks W, Wang G. Sakthikumar S, et al. Vet Comp Oncol. 2024 Mar;22(1):30-41. doi: 10.1111/vco.12944. Epub 2023 Dec 5. Vet Comp Oncol. 2024. PMID: 38053317
Novel genomic prognostic biomarkers for dogs with cancer.
Chon E, Sakthikumar S, Tang M, Hamilton MJ, Vaughan A, Smith A, Sommer B, Robat C, Manley C, Mullin C, Ohashi E, Manor E, Custis J, Intile J, Shiu KB, Parshley L, Bergman N, Sheppard-Olivares S, Hafeman S, Wright Z, Haworth D, Hendricks W, Wang G. Chon E, et al. Among authors: sakthikumar s. J Vet Intern Med. 2023 Nov-Dec;37(6):2410-2421. doi: 10.1111/jvim.16893. Epub 2023 Oct 6. J Vet Intern Med. 2023. PMID: 37801037 Free PMC article.
Using evolutionary constraint to define novel candidate driver genes in medulloblastoma.
Roy A, Sakthikumar S, Kozyrev SV, Nordin J, Pensch R, Mäkeläinen S, Pettersson M; Zoonomia Consortium; Karlsson EK, Lindblad-Toh K, Forsberg-Nilsson K. Roy A, et al. Among authors: sakthikumar s. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2300984120. doi: 10.1073/pnas.2300984120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549291 Free PMC article.
Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.
Sakthikumar S, Facista S, Whitley D, Byron SA, Ahmed Z, Warrier M, Zhu Z, Chon E, Banovich K, Haworth D, Hendricks WPD, Wang G. Sakthikumar S, et al. Vet Comp Oncol. 2023 Sep;21(3):482-491. doi: 10.1111/vco.12911. Epub 2023 May 29. Vet Comp Oncol. 2023. PMID: 37248814
Leveraging base-pair mammalian constraint to understand genetic variation and human disease.
Sullivan PF, Meadows JRS, Gazal S, Phan BN, Li X, Genereux DP, Dong MX, Bianchi M, Andrews G, Sakthikumar S, Nordin J, Roy A, Christmas MJ, Marinescu VD, Wang C, Wallerman O, Xue J, Yao S, Sun Q, Szatkiewicz J, Wen J, Huckins LM, Lawler A, Keough KC, Zheng Z, Zeng J, Wray NR, Li Y, Johnson J, Chen J; Zoonomia Consortium§; Paten B, Reilly SK, Hughes GM, Weng Z, Pollard KS, Pfenning AR, Forsberg-Nilsson K, Karlsson EK, Lindblad-Toh K. Sullivan PF, et al. Among authors: sakthikumar s. Science. 2023 Apr 28;380(6643):eabn2937. doi: 10.1126/science.abn2937. Epub 2023 Apr 28. Science. 2023. PMID: 37104612 Free PMC article.
Leveraging Base Pair Mammalian Constraint to Understand Genetic Variation and Human Disease.
Sullivan PF, Meadows JRS, Gazal S, Phan BN, Li X, Genereux DP, Dong MX, Bianchi M, Andrews G, Sakthikumar S, Nordin J, Roy A, Christmas MJ, Marinescu VD, Wallerman O, Xue JR, Li Y, Yao S, Sun Q, Szatkiewicz J, Wen J, Huckins LM, Lawler AJ, Keough KC, Zheng Z, Zeng J, Wray NR, Johnson J, Chen J; Zoonomia Consortium; Paten B, Reilly SK, Hughes GM, Weng Z, Pollard KS, Pfenning AR, Forsberg-Nilsson K, Karlsson EK, Lindblad-Toh K. Sullivan PF, et al. Among authors: sakthikumar s. bioRxiv [Preprint]. 2023 Mar 10:2023.03.10.531987. doi: 10.1101/2023.03.10.531987. bioRxiv. 2023. PMID: 36945512 Free PMC article. Updated. Preprint.
25 results