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Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions.
Lindström S, Wang L, Feng H, Majumdar A, Huo S, Macdonald J, Harrison T, Turman C, Chen H, Mancuso N, Bammler T; Breast Cancer Association Consortium (BCAC); Gallinger S, Gruber SB, Gunter MJ, Le Marchand L, Moreno V, Offit K; Colorectal Transdisciplinary Study (CORECT), Colon Cancer Family Registry Study (CCFR), Genetics And Epidemiology Of Colorectal Cancer Consortium (GECCO); De Vivo I, O'Mara TA, Spurdle AB, Tomlinson I; Endometrial Cancer Association Consortium (ECAC); Fitzgerald R, Gharahkhani P, Gockel I, Jankowski J, Macgregor S, Schumacher J, Barnholtz-Sloan J, Bondy ML, Houlston RS, Jenkins RB, Melin B, Wrensch M, Brennan P, Christiani DC, Johansson M, Mckay J, Aldrich MC, Amos CI, Landi MT, Tardon A; International Lung Cancer Consortium (ILCCO); Bishop DT, Demenais F, Goldstein AM, Iles MM, Kanetsky PA, Law MH; Ovarian Cancer Association Consortium (OCAC); Amundadottir LT, Stolzenberg-Solomon R, Wolpin BM; Pancreatic Cancer Cohort Consortium (Panscan); Klein A, Petersen G, Risch H; Pancreatic Cancer Case-Control Consortium (Panc4), The PRACTICAL Consortium; Chanock SJ, Purdue MP, Scelo G, Pharoah P, Kar S, Hung RJ, Pasaniuc B, Kraft P. Lindström S, et al. Among authors: chen h. J Natl Cancer Inst. 2023 Jun 8;115(6):712-732. doi: 10.1093/jnci/djad043. J Natl Cancer Inst. 2023. PMID: 36929942 Free PMC article.
Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals.
Chen H, Majumdar A, Wang L, Kar S, Brown KM, Feng H, Turman C, Dennis J, Easton D, Michailidou K, Simard J; Breast Cancer Association Consortium (BCAC); Bishop T, Cheng IC, Huyghe JR, Schmit SL; Colorectal Transdisciplinary Study (CORECT); Colon Cancer Family Registry Study (CCFR); Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO); O'Mara TA, Spurdle AB; Endometrial Cancer Association Consortium (ECAC); Gharahkhani P, Schumacher J, Jankowski J, Gockel I; Esophageal Cancer GWAS Consortium; Bondy ML, Houlston RS, Jenkins RB, Melin B; Glioma International Case Control Consortium (GICC); Lesseur C, Ness AR, Diergaarde B, Olshan AF; Head-Neck Cancer GWAS Consortium; Amos CI, Christiani DC, Landi MT, McKay JD; International Lung Cancer Consortium (ILCCO); Brossard M, Iles MM, Law MH, MacGregor S; Melanoma GWAS Consortium; Beesley J, Jones MR, Tyrer J, Winham SJ; Ovarian Cancer Association Consortium (OCAC); Klein AP, Petersen G, Li D, Wolpin BM; Pancreatic Cancer Case-Control Consortium (PANC4); Pancreatic Cancer Cohort Consortium (PanScan); Eeles RA, Haiman CA, Kote-Jarai Z, Schumacher FR; PRACTICAL consortium; CRUK; BPC3; CAPS; PEGASUS; Brennan P, Chanock SJ, Ga… See abstract for full author list ➔ Chen H, et al. HGG Adv. 2021 Jul 8;2(3):100041. doi: 10.1016/j.xhgg.2021.100041. Epub 2021 Jun 12. HGG Adv. 2021. PMID: 34355204 Free PMC article.
Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci.
Chen H, Fan S, Stone J, Thompson DJ, Douglas J, Li S, Scott C, Bolla MK, Wang Q, Dennis J, Michailidou K, Li C, Peters U, Hopper JL, Southey MC, Nguyen-Dumont T, Nguyen TL, Fasching PA, Behrens A, Cadby G, Murphy RA, Aronson K, Howell A, Astley S, Couch F, Olson J, Milne RL, Giles GG, Haiman CA, Maskarinec G, Winham S, John EM, Kurian A, Eliassen H, Andrulis I, Evans DG, Newman WG, Hall P, Czene K, Swerdlow A, Jones M, Pollan M, Fernandez-Navarro P, McConnell DS, Kristensen VN; NBCS Investigators; Rothstein JH, Wang P, Habel LA, Sieh W, Dunning AM, Pharoah PDP, Easton DF, Gierach GL, Tamimi RM, Vachon CM, Lindström S. Chen H, et al. Breast Cancer Res. 2022 Apr 12;24(1):27. doi: 10.1186/s13058-022-01524-0. Breast Cancer Res. 2022. PMID: 35414113 Free PMC article.
A genome-wide gene-based gene-environment interaction study of breast cancer in more than 90,000 women.
Wang X, Chen H, Middha Kapoor P, Su YR, Bolla MK, Dennis J, Dunning AM, Lush M, Wang Q, Michailidou K, Pharoah PDP, Hopper JL, Southey MC, Koutros S, Beane Freeman LE, Stone J, Rennert G, Shibli R, Murphy RA, Aronson K, Guénel P, Truong T, Teras LR, Hodge JM, Canzian F, Kaaks R, Brenner H, Arndt V, Hoppe R, Lo WY, Behrens S, Mannermaa A, Kosma VM, Jung A, Becher H, Giles GG, Haiman CA, Maskarinec G, Scott C, Winham S, Simard J, Goldberg MS, Zheng W, Long J, Troester MA, Love MI, Peng C, Tamimi R, Eliassen H, García-Closas M, Figueroa J, Ahearn T, Yang R, Evans DG, Howell A, Hall P, Czene K, Wolk A, Sandler DP, Taylor JA, Swerdlow AJ, Orr N, Lacey JV, Wang S, Olsson H, Easton DF, Milne RL, Hsu L, Kraft P, Chang-Claude J, Lindström S. Wang X, et al. Among authors: chen h. Cancer Res Commun. 2022 Apr;2(4):211-219. doi: 10.1158/2767-9764.CRC-21-0119. Epub 2022 Apr 8. Cancer Res Commun. 2022. PMID: 36303815 Free PMC article.
A genome-wide association study of mammographic texture variation.
Liu Y, Chen H, Heine J, Lindstrom S, Turman C, Warner ET, Winham SJ, Vachon CM, Tamimi RM, Kraft P, Jiang X. Liu Y, et al. Among authors: chen h. Breast Cancer Res. 2022 Nov 7;24(1):76. doi: 10.1186/s13058-022-01570-8. Breast Cancer Res. 2022. PMID: 36344993 Free PMC article.
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