Al-Karmalawy AA - Search Results

1

A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular docking and orbital analyses.

Khayat MT, Ahmed HEA, Omar AM, Muhammad YA, Mohammad KA, Malebari AM, Khayyat AN, Halawa AH, Abulkhair HS, Al-Karmalawy AA, Almaghrabi M, Alharbi M, Aljahdali AS, El-Agrody AM. Khayat MT, et al. J Biomol Struct Dyn. 2023;41(24):15243-15261. doi: 10.1080/07391102.2023.2188957. Epub 2023 Mar 13. J Biomol Struct Dyn. 2023. PMID: 36914238

2

Effect of Vitamin D supplementation in patients with liver cirrhosis having spontaneous bacterial peritonitis: a randomized controlled study.

Mohamed AA, Al-Karmalawy AA, El-Kholy AA, El-Damas DA, Abostate HM, Mostafa SM, Hamada M, Khalik Elkady MA, Hassan Y, Al-Hussain E, Khalil MG, Badawy I, Elebeedy D, Alsfouk BA, Shaheenl MM. Mohamed AA, et al. Eur Rev Med Pharmacol Sci. 2021 Nov;25(22):6908-6919. doi: 10.26355/eurrev_202111_27239. Eur Rev Med Pharmacol Sci. 2021. PMID: 34859852 Free article. Clinical Trial.

3

Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR-2 inhibitors.

El-Helby AA, Sakr H, Eissa IH, Abulkhair H, Al-Karmalawy AA, El-Adl K. El-Helby AA, et al. Arch Pharm (Weinheim). 2019 Oct;352(10):e1900113. doi: 10.1002/ardp.201900113. Epub 2019 Aug 25. Arch Pharm (Weinheim). 2019. PMID: 31448458

4

In a search for potential drug candidates for combating COVID-19: computational study revealed salvianolic acid B as a potential therapeutic targeting 3CLpro and spike proteins.

Elmaaty AA, Darwish KM, Khattab M, Elhady SS, Salah M, Hamed MIA, Al-Karmalawy AA, Saleh MM. Elmaaty AA, et al. J Biomol Struct Dyn. 2022;40(19):8866-8893. doi: 10.1080/07391102.2021.1918256. Epub 2021 Apr 30. J Biomol Struct Dyn. 2022. PMID: 33928870

5

From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity.

El-Shershaby MH, Ghiaty A, Bayoumi AH, Al-Karmalawy AA, Husseiny EM, El-Zoghbi MS, Abulkhair HS. El-Shershaby MH, et al. Bioorg Med Chem. 2021 Jul 15;42:116266. doi: 10.1016/j.bmc.2021.116266. Epub 2021 Jun 5. Bioorg Med Chem. 2021. PMID: 34126285

6

Pharmacophore-linked pyrazolo[3,4-d]pyrimidines as EGFR-TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies.

Gaber AA, El-Morsy AM, Sherbiny FF, Bayoumi AH, El-Gamal KM, El-Adl K, Al-Karmalawy AA, Ezz Eldin RR, Saleh MA, Abulkhair HS. Gaber AA, et al. Arch Pharm (Weinheim). 2021 Aug 31:e2100258. doi: 10.1002/ardp.202100258. Online ahead of print. Arch Pharm (Weinheim). 2021. PMID: 34467546

7

Telaprevir is a potential drug for repurposing against SARS-CoV-2: computational and in vitro studies.

Mahmoud A, Mostafa A, Al-Karmalawy AA, Zidan A, Abulkhair HS, Mahmoud SH, Shehata M, Elhefnawi MM, Ali MA. Mahmoud A, et al. Heliyon. 2021 Sep;7(9):e07962. doi: 10.1016/j.heliyon.2021.e07962. Epub 2021 Sep 9. Heliyon. 2021. PMID: 34518806 Free PMC article.

8

β-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: rational based design, in silico, in vitro, and SAR studies for lead optimization.

Hamed MIA, Darwish KM, Soltane R, Chrouda A, Mostafa A, Abo Shama NM, Elhady SS, Abulkhair HS, Khodir AE, Elmaaty AA, Al-Karmalawy AA. Hamed MIA, et al. RSC Adv. 2021 Nov 3;11(56):35536-35558. doi: 10.1039/d1ra04820a. eCollection 2021 Oct 28. RSC Adv. 2021. PMID: 35493159 Free PMC article.

9

Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential antitumor activity.

Hammoud MM, Khattab M, Abdel-Motaal M, Van der Eycken J, Alnajjar R, Abulkhair HS, Al-Karmalawy AA. Hammoud MM, et al. J Biomol Struct Dyn. 2023 Jul;41(11):5199-5216. doi: 10.1080/07391102.2022.2082533. Epub 2022 Jun 8. J Biomol Struct Dyn. 2023. PMID: 35674744

10

Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies.

Kutkat O, Moatasim Y, Al-Karmalawy AA, Abulkhair HS, Gomaa MR, El-Taweel AN, Abo Shama NM, GabAllah M, Mahmoud DB, Kayali G, Ali MA, Kandeil A, Mostafa A. Kutkat O, et al. Sci Rep. 2022 Jul 28;12(1):12920. doi: 10.1038/s41598-022-17082-6. Sci Rep. 2022. PMID: 35902647 Free PMC article.

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