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Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss.
Lewis JW, Frost K, Neag G, Wahid M, Finlay M, Northall EH, Abudu O, Davis ET, Powell E, Palmer C, Lu J, Rainger GE, Iqbal AJ, Chimen M, Mahmood A, Jones SW, Edwards JR, Naylor AJ, McGettrick HM. Lewis JW, et al. Among authors: chimen m. Cell Rep Med. 2024 May 21;5(5):101574. doi: 10.1016/j.xcrm.2024.101574. Cell Rep Med. 2024. PMID: 38776873
Development of ISB 1442, a CD38 and CD47 bispecific biparatopic antibody innate cell modulator for the treatment of multiple myeloma.
Grandclément C, Estoppey C, Dheilly E, Panagopoulou M, Monney T, Dreyfus C, Loyau J, Labanca V, Drake A, De Angelis S, Rubod A, Frei J, Caro LN, Blein S, Martini E, Chimen M, Matthes T, Kaya Z, Edwards CM, Edwards JR, Menoret E, Kervoelen C, Pellat-Deceunynck C, Moreau P, Mbow ML, Srivastava A, Dyson MR, Zhukovsky EA, Perro M, Sammicheli S. Grandclément C, et al. Among authors: chimen m. Nat Commun. 2024 Mar 6;15(1):2054. doi: 10.1038/s41467-024-46310-y. Nat Commun. 2024. PMID: 38448430 Free PMC article.
Preclinical characterization of ISB 1342, a CD38 × CD3 T-cell engager for relapsed/refractory multiple myeloma.
Pouleau B, Estoppey C, Suere P, Nallet E, Laurendon A, Monney T, Pais Ferreira D, Drake A, Carretero-Iglesia L, Macoin J, Berret J, Pihlgren M, Doucey MA, Gudi GS, Menon V, Udupa V, Maiti A, Borthakur G, Srivastava A, Blein S, Mbow ML, Matthes T, Kaya Z, Edwards CM, Edwards JR, Menoret E, Kervoëlen C, Pellat-Deceunynck C, Moreau P, Zhukovsky E, Perro M, Chimen M. Pouleau B, et al. Among authors: chimen m. Blood. 2023 Jul 20;142(3):260-273. doi: 10.1182/blood.2022019451. Blood. 2023. PMID: 37192303 Free PMC article.
PEPITEM modulates leukocyte trafficking to reduce obesity-induced inflammation.
Pezhman L, Hopkin SJ, Begum J, Heising S, Nasteska D, Wahid M, Ed Rainger G, Hodson DJ, Iqbal AJ, Chimen M, McGettrick HM. Pezhman L, et al. Among authors: chimen m. Clin Exp Immunol. 2023 Apr 7;212(1):1-10. doi: 10.1093/cei/uxad022. Clin Exp Immunol. 2023. PMID: 36891817 Free PMC article.
Galectin-9: A novel promoter of atherosclerosis progression.
Krautter F, Hussain MT, Zhi Z, Lezama DR, Manning JE, Brown E, Marigliano N, Raucci F, Recio C, Chimen M, Maione F, Tiwari A, McGettrick HM, Cooper D, Fisher EA, Iqbal AJ. Krautter F, et al. Among authors: chimen m. Atherosclerosis. 2022 Dec;363:57-68. doi: 10.1016/j.atherosclerosis.2022.11.014. Epub 2022 Nov 19. Atherosclerosis. 2022. PMID: 36459823 Free article.
27 results