Bougdour A - Search Results

1

Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.

Yogavel M, Bougdour A, Mishra S, Malhotra N, Chhibber-Goel J, Bellini V, Harlos K, Laleu B, Hakimi MA, Sharma A. Yogavel M, et al. Among authors: bougdour a. PLoS Pathog. 2023 Feb 28;19(2):e1011124. doi: 10.1371/journal.ppat.1011124. eCollection 2023 Feb. PLoS Pathog. 2023. PMID: 36854028 Free PMC article.

2

Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development.

Manickam Y, Malhotra N, Mishra S, Babbar P, Dusane A, Laleu B, Bellini V, Hakimi MA, Bougdour A, Sharma A. Manickam Y, et al. Among authors: bougdour a. PLoS Pathog. 2022 Mar 25;18(3):e1010363. doi: 10.1371/journal.ppat.1010363. eCollection 2022 Mar. PLoS Pathog. 2022. PMID: 35333915 Free PMC article.

3

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.

Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S. Palencia A, et al. Among authors: bougdour a. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5817-27. doi: 10.1128/AAC.00873-16. Print 2016 Oct. Antimicrob Agents Chemother. 2016. PMID: 27431220 Free PMC article.

4

Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis.

Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H, Rosenthal PJ, Cusack S, Hakimi MA. Palencia A, et al. Among authors: bougdour a. EMBO Mol Med. 2017 Mar;9(3):385-394. doi: 10.15252/emmm.201607370. EMBO Mol Med. 2017. PMID: 28148555 Free PMC article.

5

Target Identification of an Antimalarial Oxaborole Identifies AN13762 as an Alternative Chemotype for Targeting CPSF3 in Apicomplexan Parasites.

Bellini V, Swale C, Brenier-Pinchart MP, Pezier T, Georgeault S, Laurent F, Hakimi MA, Bougdour A. Bellini V, et al. Among authors: bougdour a. iScience. 2020 Nov 27;23(12):101871. doi: 10.1016/j.isci.2020.101871. eCollection 2020 Dec 18. iScience. 2020. PMID: 33336164 Free PMC article.

6

Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase.

Swale C, Bellini V, Bowler MW, Flore N, Brenier-Pinchart MP, Cannella D, Belmudes L, Mas C, Couté Y, Laurent F, Scherf A, Bougdour A, Hakimi MA. Swale C, et al. Among authors: bougdour a. Sci Transl Med. 2022 Aug 3;14(656):eabn3231. doi: 10.1126/scitranslmed.abn3231. Epub 2022 Aug 3. Sci Transl Med. 2022. PMID: 35921477 Free article.

7

Toxoplasma exports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression.

Bougdour A, Tardieux I, Hakimi MA. Bougdour A, et al. Cell Microbiol. 2014 Mar;16(3):334-43. doi: 10.1111/cmi.12255. Epub 2014 Jan 20. Cell Microbiol. 2014. PMID: 24373221 Review.

8

Toxoplasma's ways of manipulating the host transcriptome via secreted effectors.

Hakimi MA, Bougdour A. Hakimi MA, et al. Among authors: bougdour a. Curr Opin Microbiol. 2015 Aug;26:24-31. doi: 10.1016/j.mib.2015.04.003. Epub 2015 Apr 24. Curr Opin Microbiol. 2015. PMID: 25912924 Review.

9

Toxoplasma gondii gene expression is under the control of regulatory pathways acting through chromatin structure.

Bougdour A, Sautel CF, Cannella D, Braun L, Hakimi MA. Bougdour A, et al. Parasite. 2008 Sep;15(3):206-10. doi: 10.1051/parasite/2008153206. Parasite. 2008. PMID: 18814682 Free article. Review.

10

Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites.

Bougdour A, Maubon D, Baldacci P, Ortet P, Bastien O, Bouillon A, Barale JC, Pelloux H, Ménard R, Hakimi MA. Bougdour A, et al. J Exp Med. 2009 Apr 13;206(4):953-66. doi: 10.1084/jem.20082826. Epub 2009 Apr 6. J Exp Med. 2009. PMID: 19349466 Free PMC article.

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