Speer A - Search Results

1

Dysregulation of Mycobacterium marinum ESX-5 Secretion by Novel 1,2,4-oxadiazoles.

Ho VQT, Rong MK, Habjan E, Bommer SD, Pham TV, Piersma SR, Bitter W, Ruijter E, Speer A. Ho VQT, et al. Among authors: speer a. Biomolecules. 2023 Jan 21;13(2):211. doi: 10.3390/biom13020211. Biomolecules. 2023. PMID: 36830581 Free PMC article.

2

iniBAC induction Is Vitamin B12- and MutAB-dependent in Mycobacterium marinum.

Boot M, Sparrius M, Jim KK, Commandeur S, Speer A, van de Weerd R, Bitter W. Boot M, et al. Among authors: speer a. J Biol Chem. 2016 Sep 16;291(38):19800-12. doi: 10.1074/jbc.M116.724088. Epub 2016 Jul 29. J Biol Chem. 2016. PMID: 27474746 Free PMC article.

3

Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose.

Boot M, van Winden VJC, Sparrius M, van de Weerd R, Speer A, Ummels R, Rustad T, Sherman DR, Bitter W. Boot M, et al. Among authors: speer a. PLoS Genet. 2017 Dec 27;13(12):e1007131. doi: 10.1371/journal.pgen.1007131. eCollection 2017 Dec. PLoS Genet. 2017. PMID: 29281637 Free PMC article.

4

Accelerating Early Antituberculosis Drug Discovery by Creating Mycobacterial Indicator Strains That Predict Mode of Action.

Boot M, Commandeur S, Subudhi AK, Bahira M, Smith TC 2nd, Abdallah AM, van Gemert M, Lelièvre J, Ballell L, Aldridge BB, Pain A, Speer A, Bitter W. Boot M, et al. Among authors: speer a. Antimicrob Agents Chemother. 2018 Jun 26;62(7):e00083-18. doi: 10.1128/AAC.00083-18. Print 2018 Jul. Antimicrob Agents Chemother. 2018. PMID: 29661879 Free PMC article.

5

Optimization of secretion and surface localization of heterologous OVA protein in mycobacteria by using LipY as a carrier.

Burggraaf MJ, Ates LS, Speer A, van der Kuij K, Kuijl C, Bitter W. Burggraaf MJ, et al. Among authors: speer a. Microb Cell Fact. 2019 Mar 6;18(1):44. doi: 10.1186/s12934-019-1093-1. Microb Cell Fact. 2019. PMID: 30841891 Free PMC article.

6

Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease.

Burggraaf MJ, Speer A, Meijers AS, Ummels R, van der Sar AM, Korotkov KV, Bitter W, Kuijl C. Burggraaf MJ, et al. Among authors: speer a. mBio. 2019 Oct 29;10(5):e01951-19. doi: 10.1128/mBio.01951-19. mBio. 2019. PMID: 31662454 Free PMC article.

7

Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis.

Ortega Ugalde S, Wallraven K, Speer A, Bitter W, Grossmann TN, Commandeur JNM. Ortega Ugalde S, et al. Among authors: speer a. Biochem Pharmacol. 2020 Jul;177:113938. doi: 10.1016/j.bcp.2020.113938. Epub 2020 Mar 26. Biochem Pharmacol. 2020. PMID: 32224137 Free article.

8

Efficient genome editing in pathogenic mycobacteria using Streptococcus thermophilus CRISPR1-Cas9.

Meijers AS, Troost R, Ummels R, Maaskant J, Speer A, Nejentsev S, Bitter W, Kuijl CP. Meijers AS, et al. Among authors: speer a. Tuberculosis (Edinb). 2020 Sep;124:101983. doi: 10.1016/j.tube.2020.101983. Epub 2020 Aug 12. Tuberculosis (Edinb). 2020. PMID: 32829077 Free PMC article.

9

Heterologous Expression of ethA and katG in Mycobacterium marinum Enables the Rapid Identification of New Prodrugs Active against Mycobacterium tuberculosis.

Ho VQT, Verboom T, Rong MK, Habjan E, Bitter W, Speer A. Ho VQT, et al. Among authors: speer a. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e01445-20. doi: 10.1128/AAC.01445-20. Print 2021 Mar 18. Antimicrob Agents Chemother. 2021. PMID: 33495223 Free PMC article.

10

Mycobacterium tuberculosis Toxin CpnT Is an ESX-5 Substrate and Requires Three Type VII Secretion Systems for Intracellular Secretion.

Izquierdo Lafuente B, Ummels R, Kuijl C, Bitter W, Speer A. Izquierdo Lafuente B, et al. Among authors: speer a. mBio. 2021 Mar 2;12(2):e02983-20. doi: 10.1128/mBio.02983-20. mBio. 2021. PMID: 33653883 Free PMC article.

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