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CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation.
Front Immunol. 2023 Feb 1;14:1110482. doi: 10.3389/fimmu.2023.1110482. eCollection 2023.
Front Immunol. 2023.
PMID: 36817444
Free PMC article.
CD28 and 41BB Costimulatory Domains Alone or in Combination Differentially Influence Cell Surface Dynamics and Organization of Chimeric Antigen Receptors and Early Activation of CAR T Cells.
Mezősi-Csaplár M, Szöőr Á, Vereb G.
Mezősi-Csaplár M, et al.
Cancers (Basel). 2023 Jun 7;15(12):3081. doi: 10.3390/cancers15123081.
Cancers (Basel). 2023.
PMID: 37370693
Free PMC article.
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Universal CAR T cells targeted to HER2 with a biotin-trastuzumab soluble linker penetrate spheroids and large tumor xenografts that are inherently resistant to trastuzumab mediated ADCC.
Nagy L, Mezősi-Csaplár M, Rebenku I, Vereb G, Szöőr Á.
Nagy L, et al. Among authors: mezosi csaplar m.
Front Immunol. 2024 Mar 18;15:1365172. doi: 10.3389/fimmu.2024.1365172. eCollection 2024.
Front Immunol. 2024.
PMID: 38562932
Free PMC article.
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