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Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells.
Nguyen T, Urrutia-Cabrera D, Wang L, Lees JG, Wang JH, Hung SSC, Hewitt AW, Edwards TL, McLenachan S, Chen FK, Lim SY, Luu CD, Guymer R, Wong RCB. Nguyen T, et al. Among authors: hewitt aw. Aging (Albany NY). 2023 Feb 16;15(6):1713-1733. doi: 10.18632/aging.204522. Epub 2023 Feb 16. Aging (Albany NY). 2023. PMID: 36795578 Free PMC article.
TAK1 blockade as a therapy for retinal neovascularization.
Wang JH, Lin FL, Chen J, Zhu L, Chuang YF, Tu L, Ma C, Ling D, Hewitt AW, Tseng CL, Shah MH, Bui BV, van Wijngaarden P, Dusting GJ, Wang PY, Liu GS. Wang JH, et al. Among authors: hewitt aw. Pharmacol Res. 2023 Jan;187:106617. doi: 10.1016/j.phrs.2022.106617. Epub 2022 Dec 16. Pharmacol Res. 2023. PMID: 36535572 Free article.
A semi-automated pipeline for quantifying drusen-like deposits in human induced pluripotent stem cell-derived retinal pigment epithelium cells.
Hall J, Daniszewski M, Cheung S, Shobhana K, Kumar H, Liang HH, Beetham H, Cho E, Abbott C, Hewitt AW, Simpson KJ, Guymer RH, Paull D, Pébay A, Lidgerwood GE. Hall J, et al. Among authors: hewitt aw. SLAS Technol. 2023 Aug 30:S2472-6303(23)00055-9. doi: 10.1016/j.slast.2023.08.006. Online ahead of print. SLAS Technol. 2023. PMID: 37657710 Free article.
Universal cell donor lines: A review of the current research.
Simpson A, Hewitt AW, Fairfax KA. Simpson A, et al. Among authors: hewitt aw. Stem Cell Reports. 2023 Nov 14;18(11):2038-2046. doi: 10.1016/j.stemcr.2023.09.010. Epub 2023 Oct 12. Stem Cell Reports. 2023. PMID: 37832541 Free PMC article. Review.
Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm.
Wu Z, Shen S, Mizikovsky D, Cao Y, Naval-Sanchez M, Tan SZ, Alvarez YD, Sun Y, Chen X, Zhao Q, Kim D, Yang P, Hill TA, Jones A, Fairlie DP, Pébay A, Hewitt AW, Tam PPL, White MD, Nefzger CM, Palpant NJ. Wu Z, et al. Among authors: hewitt aw. Dev Cell. 2024 Mar 25;59(6):705-722.e8. doi: 10.1016/j.devcel.2024.01.019. Epub 2024 Feb 13. Dev Cell. 2024. PMID: 38354738
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries.
Gharahkhani P, Jorgenson E, Hysi P, Khawaja AP, Pendergrass S, Han X, Ong JS, Hewitt AW, Segrè AV, Rouhana JM, Hamel AR, Igo RP Jr, Choquet H, Qassim A, Josyula NS, Cooke Bailey JN, Bonnemaijer PWM, Iglesias A, Siggs OM, Young TL, Vitart V, Thiadens AAHJ, Karjalainen J, Uebe S, Melles RB, Nair KS, Luben R, Simcoe M, Amersinghe N, Cree AJ, Hohn R, Poplawski A, Chen LJ, Rong SS, Aung T, Vithana EN; NEIGHBORHOOD consortium; ANZRAG consortium; Biobank Japan project; FinnGen study; UK Biobank Eye and Vision Consortium; GIGA study group; 23 and Me Research Team; Tamiya G, Shiga Y, Yamamoto M, Nakazawa T, Currant H, Birney E, Wang X, Auton A, Lupton MK, Martin NG, Ashaye A, Olawoye O, Williams SE, Akafo S, Ramsay M, Hashimoto K, Kamatani Y, Akiyama M, Momozawa Y, Foster PJ, Khaw PT, Morgan JE, Strouthidis NG, Kraft P, Kang JH, Pang CP, Pasutto F, Mitchell P, Lotery AJ, Palotie A, van Duijn C, Haines JL, Hammond C, Pasquale LR, Klaver CCW, Hauser M, Khor CC, Mackey DA, Kubo M, Cheng CY, Craig JE, MacGregor S, Wiggs JL. Gharahkhani P, et al. Among authors: hewitt aw. Nat Commun. 2021 Feb 24;12(1):1258. doi: 10.1038/s41467-020-20851-4. Nat Commun. 2021. PMID: 33627673 Free PMC article.
Deep Learning-Based Identification of Intraocular Pressure-Associated Genes Influencing Trabecular Meshwork Cell Morphology.
Greatbatch CJ, Lu Q, Hung S, Tran SN, Wing K, Liang H, Han X, Zhou T, Siggs OM, Mackey DA, Liu GS, Cook AL, Powell JE, Craig JE, MacGregor S, Hewitt AW. Greatbatch CJ, et al. Among authors: hewitt aw. Ophthalmol Sci. 2024 Mar 5;4(4):100504. doi: 10.1016/j.xops.2024.100504. eCollection 2024 Jul-Aug. Ophthalmol Sci. 2024. PMID: 38682030 Free PMC article.
Relationship Between Oral Health and Glaucoma Traits in the United Kingdom.
Lee RH, Kang JH, Wiggs JL, Wagner SK, Khawaja AP, Pasquale LR; Modifiable Risk Factors for Glaucoma Collaboration, the UK Biobank Eye and Vision Consortium, and the International Glaucoma Genetics Consortium. Lee RH, et al. J Glaucoma. 2024 Jun 1;33(6):400-408. doi: 10.1097/IJG.0000000000002370. Epub 2024 Mar 5. J Glaucoma. 2024. PMID: 38506820
416 results