Gestwicki JE - Search Results

1

Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States.

Montgomery KM, Carroll EC, Thwin AC, Quddus AY, Hodges P, Southworth DR, Gestwicki JE. Montgomery KM, et al. Among authors: gestwicki je. J Am Chem Soc. 2023 Feb 8;145(7):3926-36. doi: 10.1021/jacs.2c08004. Online ahead of print. J Am Chem Soc. 2023. PMID: 36753572 Free PMC article.

2

The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.

Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D. Connarn JN, et al. Among authors: gestwicki je. J Biol Chem. 2014 Jan 31;289(5):2908-17. doi: 10.1074/jbc.M113.519421. Epub 2013 Dec 10. J Biol Chem. 2014. PMID: 24327656 Free PMC article.

3

Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.

Assimon VA, Southworth DR, Gestwicki JE. Assimon VA, et al. Among authors: gestwicki je. Biochemistry. 2015 Dec 8;54(48):7120-31. doi: 10.1021/acs.biochem.5b00801. Epub 2015 Nov 25. Biochemistry. 2015. PMID: 26565746 Free PMC article.

4

Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.

Martin MD, Baker JD, Suntharalingam A, Nordhues BA, Shelton LB, Zheng D, Sabbagh JJ, Haystead TA, Gestwicki JE, Dickey CA. Martin MD, et al. Among authors: gestwicki je. ACS Chem Biol. 2016 Jul 15;11(7):2041-8. doi: 10.1021/acschembio.6b00223. Epub 2016 May 26. ACS Chem Biol. 2016. PMID: 27177119 Free PMC article.

5

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins.

Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE. Rauch JN, et al. Among authors: gestwicki je. J Mol Biol. 2017 Jan 6;429(1):128-141. doi: 10.1016/j.jmb.2016.11.013. Epub 2016 Nov 21. J Mol Biol. 2017. PMID: 27884606 Free PMC article.

6

X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.

Cesa LC, Shao H, Srinivasan SR, Tse E, Jain C, Zuiderweg ERP, Southworth DR, Mapp AK, Gestwicki JE. Cesa LC, et al. Among authors: gestwicki je. J Biol Chem. 2018 Feb 16;293(7):2370-2380. doi: 10.1074/jbc.RA117.000634. Epub 2017 Dec 18. J Biol Chem. 2018. PMID: 29255093 Free PMC article.

7

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau.

Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE. Freilich R, et al. Among authors: gestwicki je. Nat Commun. 2018 Nov 1;9(1):4563. doi: 10.1038/s41467-018-07012-4. Nat Commun. 2018. PMID: 30385828 Free PMC article.

8

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.

Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R, Baik J, He M, Gong S, Roberson ED, Karch CM, Gestwicki JE, Xu K, Kosik KS, Gan L. Sohn PD, et al. Among authors: gestwicki je. Neuron. 2019 Nov 6;104(3):458-470.e5. doi: 10.1016/j.neuron.2019.08.008. Epub 2019 Sep 18. Neuron. 2019. PMID: 31542321 Free PMC article.

9

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.

Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M. Chen JJ, et al. Among authors: gestwicki je. J Biol Chem. 2019 Dec 13;294(50):18952-18966. doi: 10.1074/jbc.RA119.009432. Epub 2019 Oct 2. J Biol Chem. 2019. PMID: 31578281 Free PMC article.

10

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.

Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Carvalho Martins L, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, Kratochvil HT; QCRG Structural Biology Consortium; Aimon A, Bennett JM, Brandao Neto J, Cohen AE, Dias A, Douangamath A, Dunnett L, Fedorov O, Ferla MP, Fuchs MR, Gorrie-Stone TJ, Holton JM, Johnson MG, Krojer T, Meigs G, Powell AJ, Rack JGM, Rangel VL, Russi S, Skyner RE, Smith CA, Soares AS, Wierman JL, Zhu K, O'Brien P, Jura N, Ashworth A, Irwin JJ, Thompson MC, Gestwicki JE, von Delft F, Shoichet BK, Fraser JS, Ahel I. Schuller M, et al. Among authors: gestwicki je. Sci Adv. 2021 Apr 14;7(16):eabf8711. doi: 10.1126/sciadv.abf8711. Print 2021 Apr. Sci Adv. 2021. PMID: 33853786 Free PMC article.

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