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Safety, immunogenicity and efficacy of the self-amplifying mRNA ARCT-154 COVID-19 vaccine: pooled phase 1, 2, 3a and 3b randomized, controlled trials.
Hồ NT, Hughes SG, Ta VT, Phan LT, Đỗ Q, Nguyễn TV, Phạm ATV, Thị Ngọc Đặng M, Nguyễn LV, Trịnh QV, Phạm HN, Chử MV, Nguyễn TT, Lương QC, Tường Lê VT, Nguyễn TV, Trần LT, Thi Van Luu A, Nguyen AN, Nguyen NT, Vu HS, Edelman JM, Parker S, Sullivan B, Sullivan S, Ruan Q, Clemente B, Luk B, Lindert K, Berdieva D, Murphy K, Sekulovich R, Greener B, Smolenov I, Chivukula P, Nguyễn VT, Nguyen XH. Hồ NT, et al. Among authors: chivukula p. Nat Commun. 2024 May 14;15(1):4081. doi: 10.1038/s41467-024-47905-1. Nat Commun. 2024. PMID: 38744844 Free PMC article. Clinical Trial.
Engineered tRNAs suppress nonsense mutations in cells and in vivo.
Albers S, Allen EC, Bharti N, Davyt M, Joshi D, Perez-Garcia CG, Santos L, Mukthavaram R, Delgado-Toscano MA, Molina B, Kuakini K, Alayyoubi M, Park KJ, Acharya G, Gonzalez JA, Sagi A, Birket SE, Tearney GJ, Rowe SM, Manfredi C, Hong JS, Tachikawa K, Karmali P, Matsuda D, Sorscher EJ, Chivukula P, Ignatova Z. Albers S, et al. Among authors: chivukula p. Nature. 2023 Jun;618(7966):842-848. doi: 10.1038/s41586-023-06133-1. Epub 2023 May 31. Nature. 2023. PMID: 37258671 Free PMC article.
Extensive diet-induced atherosclerosis in scavenger receptor class B type 1-deficient mice is associated with substantial leukocytosis and elevated vascular cell adhesion molecule-1 expression in coronary artery endothelium.
Fuller MT, Dadoo O, Xiong T, Chivukula P, MacDonald ME, Lee SK, Austin RC, Igdoura SA, Trigatti BL. Fuller MT, et al. Among authors: chivukula p. Front Physiol. 2023 Jan 12;13:1023397. doi: 10.3389/fphys.2022.1023397. eCollection 2022. Front Physiol. 2023. PMID: 36714321 Free PMC article.
A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine.
Low JG, de Alwis R, Chen S, Kalimuddin S, Leong YS, Mah TKL, Yuen N, Tan HC, Zhang SL, Sim JXY, Chan YFZ, Syenina A, Yee JX, Ong EZ, Sekulovich R, Sullivan BB, Lindert K, Sullivan SM, Chivukula P, Hughes SG, Ooi EE. Low JG, et al. Among authors: chivukula p. NPJ Vaccines. 2022 Dec 13;7(1):161. doi: 10.1038/s41541-022-00590-x. NPJ Vaccines. 2022. PMID: 36513697 Free PMC article.
Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine.
Ong EZ, Yee JX, Ooi JSG, Syenina A, de Alwis R, Chen S, Sim JXY, Kalimuddin S, Leong YS, Chan YFZ, Sekulovich R, Sullivan BM, Lindert K, Sullivan SB, Chivukula P, Hughes SG, Low JG, Ooi EE, Chan KR. Ong EZ, et al. Among authors: chivukula p. NPJ Vaccines. 2022 Nov 28;7(1):154. doi: 10.1038/s41541-022-00573-y. NPJ Vaccines. 2022. PMID: 36443317 Free PMC article.
Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions.
Milbank E, Díaz-Trelles R, Dragano N, Latorre J, Mukthavaram R, Mayneris-Perxachs J, Ortega F, Federici M, Burcelin R, Karmali PP, Tachikawa K, Chivukula P, López M, Fernández-Real JM, Moreno-Navarrete JM. Milbank E, et al. Among authors: chivukula p. Pharmacol Res. 2023 Jan;187:106562. doi: 10.1016/j.phrs.2022.106562. Epub 2022 Nov 21. Pharmacol Res. 2023. PMID: 36410673 Free article.
Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation.
Latorre J, Díaz-Trelles R, Comas F, Gavaldà-Navarro A, Milbank E, Dragano N, Morón-Ros S, Mukthavaram R, Ortega F, Castells-Nobau A, Oliveras-Cañellas N, Ricart W, Karmali PP, Tachikawa K, Chivukula P, Villarroya F, López M, Giralt M, Fernández-Real JM, Moreno-Navarrete JM. Latorre J, et al. Among authors: chivukula p. Mol Ther Nucleic Acids. 2022 Aug 5;29:599-613. doi: 10.1016/j.omtn.2022.08.003. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 36090751 Free PMC article.
Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice.
Comas F, Díaz-Trelles R, Gavaldà-Navarro A, Milbank E, Dragano N, Morón-Ros S, Mukthavaram R, Latorre J, Ortega F, Arnoriaga-Rodriguez M, Oliveras-Cañellas N, Ricart W, Karmali PP, Tachikawa K, Chivukula P, Villarroya F, Giralt M, López M, Fernández-Real JM, Moreno-Navarrete JM. Comas F, et al. Among authors: chivukula p. Biomed Pharmacother. 2022 Jul;151:113156. doi: 10.1016/j.biopha.2022.113156. Epub 2022 May 25. Biomed Pharmacother. 2022. PMID: 35643066 Free article.
Lipid nanoparticle delivers phenylalanine ammonia lyase mRNA to the liver leading to catabolism and clearance of phenylalanine in a phenylketonuria mouse model.
Diaz-Trelles R, Lee S, Kuakini K, Park J, Dukanovic A, Gonzalez JA, Dam T, Kim JH, Vega JB, Sablad M, Karmali PP, Tachikawa K, Chivukula P. Diaz-Trelles R, et al. Among authors: chivukula p. Mol Genet Metab Rep. 2022 May 14;32:100882. doi: 10.1016/j.ymgmr.2022.100882. eCollection 2022 Sep. Mol Genet Metab Rep. 2022. PMID: 35600090 Free PMC article.
27 results