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Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2. Activation by sodium and absolute dependence on bivalent cations.
Godoy A, Ormazabal V, Moraga-Cid G, Zúñiga FA, Sotomayor P, Barra V, Vasquez O, Montecinos V, Mardones L, Guzmán C, Villagrán M, Aguayo LG, Oñate SA, Reyes AM, Cárcamo JG, Rivas CI, Vera JC. Godoy A, et al. Among authors: rivas ci. J Biol Chem. 2007 Jan 5;282(1):615-24. doi: 10.1074/jbc.M608300200. Epub 2006 Sep 29. J Biol Chem. 2007. PMID: 17012227 Free article.
Vitamin C transporters.
Rivas CI, Zúñiga FA, Salas-Burgos A, Mardones L, Ormazabal V, Vera JC. Rivas CI, et al. J Physiol Biochem. 2008 Dec;64(4):357-75. doi: 10.1007/BF03174092. J Physiol Biochem. 2008. PMID: 19391462 Review.
Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells.
Mardones L, Zúñiga FA, Villagrán M, Sotomayor K, Mendoza P, Escobar D, González M, Ormazabal V, Maldonado M, Oñate G, Angulo C, Concha II, Reyes AM, Cárcamo JG, Barra V, Vera JC, Rivas CI. Mardones L, et al. Among authors: rivas ci. Free Radic Biol Med. 2012 May 1;52(9):1874-87. doi: 10.1016/j.freeradbiomed.2012.02.017. Epub 2012 Feb 18. Free Radic Biol Med. 2012. PMID: 22348976
Sustained blockade of ascorbic acid transport associated with marked SVCT1 loss in rat hepatocytes containing increased ascorbic acid levels after partial hepatectomy.
Maldonado M, Inostroza E, Peña E, Moncada N, Mardones L, Medina JL, Muñoz A, Gatica M, Villagrán M, Escobar E, Mendoza P, Roa FJ, González M, Guzmán P, Gutiérrez-Castro FA, Sweet K, Muñoz-Montesino C, Vera JC, Rivas CI. Maldonado M, et al. Among authors: rivas ci. Free Radic Biol Med. 2017 Jul;108:655-667. doi: 10.1016/j.freeradbiomed.2017.04.006. Epub 2017 Apr 15. Free Radic Biol Med. 2017. PMID: 28419867
GLUT1 and GLUT8 support lactose synthesis in Golgi of murine mammary epithelial cells.
Villagrán M, Muñoz M, Inostroza E, Venegas C, Ruminot I, Parra-Valencia E, Maldonado M, Del Pozo R, Rivas CI, Vera JC, Mardones L. Villagrán M, et al. Among authors: rivas ci. J Physiol Biochem. 2019 Jun;75(2):209-215. doi: 10.1007/s13105-019-00679-3. Epub 2019 Apr 24. J Physiol Biochem. 2019. PMID: 31020623
Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione.
Montecinos V, Guzmán P, Barra V, Villagrán M, Muñoz-Montesino C, Sotomayor K, Escobar E, Godoy A, Mardones L, Sotomayor P, Guzmán C, Vásquez O, Gallardo V, van Zundert B, Bono MR, Oñate SA, Bustamante M, Cárcamo JG, Rivas CI, Vera JC. Montecinos V, et al. Among authors: rivas ci. J Biol Chem. 2007 May 25;282(21):15506-15. doi: 10.1074/jbc.M608361200. Epub 2007 Apr 2. J Biol Chem. 2007. PMID: 17403685 Free article.
Cis-regulatory elements involved in species-specific transcriptional regulation of the SVCT1 gene in rat and human hepatoma cells.
Muñoz A, Villagrán M, Guzmán P, Solíz C, Gatica M, Aylwin C, Sweet K, Maldonado M, Escobar E, Reyes AM, Toledo JR, Sánchez O, Oñate SA, Carlos Vera J, Rivas CI. Muñoz A, et al. Among authors: rivas ci. Free Radic Biol Med. 2015 Aug;85:183-96. doi: 10.1016/j.freeradbiomed.2015.04.024. Epub 2015 Apr 28. Free Radic Biol Med. 2015. PMID: 25933589
Transport of Vitamin C in Cancer.
Muñoz-Montesino C, Peña E, Roa FJ, Sotomayor K, Escobar E, Rivas CI. Muñoz-Montesino C, et al. Among authors: rivas ci. Antioxid Redox Signal. 2021 Jul;35(1):61-74. doi: 10.1089/ars.2020.8166. Epub 2021 Apr 23. Antioxid Redox Signal. 2021. PMID: 33607936 Review.
Bone stroma-derived cells change coregulators recruitment to androgen receptor and decrease cell proliferation in androgen-sensitive and castration-resistant prostate cancer cells.
Villagran MA, Gutierrez-Castro FA, Pantoja DF, Alarcon JC, Fariña MA, Amigo RF, Muñoz-Godoy NA, Pinilla MG, Peña EA, Gonzalez-Chavarria I, Toledo JR, Rivas CI, Vera JC, McNerney EM, Onate SA. Villagran MA, et al. Among authors: rivas ci. Biochem Biophys Res Commun. 2015 Nov 27;467(4):1039-45. doi: 10.1016/j.bbrc.2015.10.009. Epub 2015 Oct 20. Biochem Biophys Res Commun. 2015. PMID: 26494300
78 results