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Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases.
Zhan N, Wang B, Martens N, Liu Y, Zhao S, Voortman G, van Rooij J, Leijten F, Vanmierlo T, Kuipers F, Jonker JW, Bloks VW, Lütjohann D, Palumbo M, Zimetti F, Adorni MP, Liu H, Mulder MT. Zhan N, et al. Among authors: vanmierlo t. Int J Mol Sci. 2023 Jan 9;24(2):1290. doi: 10.3390/ijms24021290. Int J Mol Sci. 2023. PMID: 36674804 Free PMC article.
Generation of induced pluripotent stem cell (iPSC) lines carrying a heterozygous (UKWMPi002-A-1) and null mutant knockout (UKWMPi002-A-2) of Cadherin 13 associated with neurodevelopmental disorders using CRISPR/Cas9.
Vitale MR, Zöller JEM, Jansch C, Janz A, Edenhofer F, Klopocki E, van den Hove D, Vanmierlo T, Rivero O, Nadif Kasri N, Ziegler GC, Lesch KP. Vitale MR, et al. Among authors: vanmierlo t. Stem Cell Res. 2021 Mar;51:102169. doi: 10.1016/j.scr.2021.102169. Epub 2021 Jan 11. Stem Cell Res. 2021. PMID: 33486346 Free article.
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses.
Bruno O, Fedele E, Prickaerts J, Parker LA, Canepa E, Brullo C, Cavallero A, Gardella E, Balbi A, Domenicotti C, Bollen E, Gijselaers HJ, Vanmierlo T, Erb K, Limebeer CL, Argellati F, Marinari UM, Pronzato MA, Ricciarelli R. Bruno O, et al. Among authors: vanmierlo t. Br J Pharmacol. 2011 Dec;164(8):2054-63. doi: 10.1111/j.1476-5381.2011.01524.x. Br J Pharmacol. 2011. PMID: 21649644 Free PMC article.
Myelin alters the inflammatory phenotype of macrophages by activating PPARs.
Bogie JF, Jorissen W, Mailleux J, Nijland PG, Zelcer N, Vanmierlo T, Van Horssen J, Stinissen P, Hellings N, Hendriks JJ. Bogie JF, et al. Among authors: vanmierlo t. Acta Neuropathol Commun. 2013 Aug 2;1:43. doi: 10.1186/2051-5960-1-43. Acta Neuropathol Commun. 2013. PMID: 24252308 Free PMC article.
From OPC to Oligodendrocyte: An Epigenetic Journey.
Tiane A, Schepers M, Rombaut B, Hupperts R, Prickaerts J, Hellings N, van den Hove D, Vanmierlo T. Tiane A, et al. Among authors: vanmierlo t. Cells. 2019 Oct 11;8(10):1236. doi: 10.3390/cells8101236. Cells. 2019. PMID: 31614602 Free PMC article. Review.
CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia.
Lodder C, Scheyltjens I, Stancu IC, Botella Lucena P, Gutiérrez de Ravé M, Vanherle S, Vanmierlo T, Cremers N, Vanrusselt H, Brône B, Hanseeuw B, Octave JN, Bottelbergs A, Movahedi K, Dewachter I. Lodder C, et al. Among authors: vanmierlo t. Acta Neuropathol Commun. 2021 Jun 8;9(1):108. doi: 10.1186/s40478-021-01204-8. Acta Neuropathol Commun. 2021. PMID: 34103079 Free PMC article.
Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system.
Llufriu-Dabén G, Carrete A, Chierto E, Mailleux J, Camand E, Simon A, Vanmierlo T, Rose C, Allinquant B, Hendriks JJA, Massaad C, Meffre D, Jafarian-Tehrani M. Llufriu-Dabén G, et al. Among authors: vanmierlo t. Neurobiol Dis. 2018 Jan;109(Pt A):11-24. doi: 10.1016/j.nbd.2017.09.008. Epub 2017 Sep 18. Neurobiol Dis. 2018. PMID: 28923597
Dietary advanced glycation endproducts (AGEs) increase their concentration in plasma and tissues, result in inflammation and modulate gut microbial composition in mice; evidence for reversibility.
van Dongen KCW, Linkens AMA, Wetzels SMW, Wouters K, Vanmierlo T, van de Waarenburg MPH, Scheijen JLJM, de Vos WM, Belzer C, Schalkwijk CG. van Dongen KCW, et al. Among authors: vanmierlo t. Food Res Int. 2021 Sep;147:110547. doi: 10.1016/j.foodres.2021.110547. Epub 2021 Jun 18. Food Res Int. 2021. PMID: 34399524
104 results