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Improved cytosine base editors generated from TadA variants.
Nat Biotechnol. 2023 May;41(5):686-697. doi: 10.1038/s41587-022-01611-9. Epub 2023 Jan 9.
Nat Biotechnol. 2023.
PMID: 36624149
Free PMC article.
Directed evolution of adenine base editors with increased activity and therapeutic application.
Gaudelli NM, Lam DK, Rees HA, Solá-Esteves NM, Barrera LA, Born DA, Edwards A, Gehrke JM, Lee SJ, Liquori AJ, Murray R, Packer MS, Rinaldi C, Slaymaker IM, Yen J, Young LE, Ciaramella G.
Gaudelli NM, et al. Among authors: gehrke jm.
Nat Biotechnol. 2020 Jul;38(7):892-900. doi: 10.1038/s41587-020-0491-6. Epub 2020 Apr 13.
Nat Biotechnol. 2020.
PMID: 32284586
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Cytosine base editing enables quadruple-edited allogeneic CART cells for T-ALL.
Diorio C, Murray R, Naniong M, Barrera L, Camblin A, Chukinas J, Coholan L, Edwards A, Fuller T, Gonzales C, Grupp SA, Ladd A, Le M, Messana A, Musenge F, Newman H, Poh YC, Poulin H, Ryan T, Shraim R, Tasian SK, Vincent T, Young L, Zhang Y, Ciaramella G, Gehrke J, Teachey DT.
Diorio C, et al.
Blood. 2022 Aug 11;140(6):619-629. doi: 10.1182/blood.2022015825.
Blood. 2022.
PMID: 35560156
Free PMC article.
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An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities.
Gehrke JM, Cervantes O, Clement MK, Wu Y, Zeng J, Bauer DE, Pinello L, Joung JK.
Gehrke JM, et al.
Nat Biotechnol. 2018 Nov;36(10):977-982. doi: 10.1038/nbt.4199. Epub 2018 Jul 30.
Nat Biotechnol. 2018.
PMID: 30059493
Free PMC article.
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CRISPResso2 provides accurate and rapid genome editing sequence analysis.
Clement K, Rees H, Canver MC, Gehrke JM, Farouni R, Hsu JY, Cole MA, Liu DR, Joung JK, Bauer DE, Pinello L.
Clement K, et al. Among authors: gehrke jm.
Nat Biotechnol. 2019 Mar;37(3):224-226. doi: 10.1038/s41587-019-0032-3.
Nat Biotechnol. 2019.
PMID: 30809026
Free PMC article.
No abstract available.
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Therapeutic base editing of human hematopoietic stem cells.
Zeng J, Wu Y, Ren C, Bonanno J, Shen AH, Shea D, Gehrke JM, Clement K, Luk K, Yao Q, Kim R, Wolfe SA, Manis JP, Pinello L, Joung JK, Bauer DE.
Zeng J, et al. Among authors: gehrke jm.
Nat Med. 2020 Apr;26(4):535-541. doi: 10.1038/s41591-020-0790-y. Epub 2020 Mar 16.
Nat Med. 2020.
PMID: 32284612
Free PMC article.
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