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Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice.
Jarvis R, Josephine Ng SF, Nathanson AJ, Cardarelli RA, Abiraman K, Wade F, Evans-Strong A, Fernandez-Campa MP, Deeb TZ, Smalley JL, Jamier T, Gurrell IK, McWilliams L, Kawatkar A, Conway LC, Wang Q, Burli RW, Brandon NJ, Chessell IP, Goldman AJ, Maguire JL, Moss SJ. Jarvis R, et al. Among authors: smalley jl. Cell Rep Med. 2023 Mar 21;4(3):100957. doi: 10.1016/j.xcrm.2023.100957. Epub 2023 Mar 7. Cell Rep Med. 2023. PMID: 36889319 Free PMC article.
KCC2 is required for the survival of mature neurons but not for their development.
Kontou G, Josephine Ng SF, Cardarelli RA, Howden JH, Choi C, Ren Q, Rodriguez Santos MA, Bope CE, Dengler JS, Kelley MR, Davies PA, Kittler JT, Brandon NJ, Moss SJ, Smalley JL. Kontou G, et al. Among authors: smalley jl. J Biol Chem. 2021 Jan-Jun;296:100364. doi: 10.1016/j.jbc.2021.100364. Epub 2021 Feb 2. J Biol Chem. 2021. PMID: 33539918 Free PMC article.
Nanoengineered Disruption of Heat Shock Protein 90 Targets Drug-Induced Resistance and Relieves Natural Killer Cell Suppression in Breast Cancer.
Smalley M, Natarajan SK, Mondal J, Best D, Goldman D, Shanthappa B, Pellowe M, Dash C, Saha T, Khiste S, Ramadurai N, Eton EO, Smalley JL, Brown A, Thayakumar A, Rahman M, Arai K, Kohandel M, Sengupta S, Goldman A. Smalley M, et al. Among authors: smalley jl. Cancer Res. 2020 Dec 1;80(23):5355-5366. doi: 10.1158/0008-5472.CAN-19-4036. Epub 2020 Oct 19. Cancer Res. 2020. PMID: 33077554 Free PMC article.
Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures.
Nathanson AJ, Zhang Y, Smalley JL, Ollerhead TA, Rodriguez Santos MA, Andrews PM, Wobst HJ, Moore YE, Brandon NJ, Hines RM, Davies PA, Moss SJ. Nathanson AJ, et al. Among authors: smalley jl. Cell Rep. 2019 Jul 16;28(3):670-681.e8. doi: 10.1016/j.celrep.2019.06.014. Cell Rep. 2019. PMID: 31315046 Free PMC article.
20 results