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A random six-phase switch regulates pneumococcal virulence via global epigenetic changes.
Manso AS, Chai MH, Atack JM, Furi L, De Ste Croix M, Haigh R, Trappetti C, Ogunniyi AD, Shewell LK, Boitano M, Clark TA, Korlach J, Blades M, Mirkes E, Gorban AN, Paton JC, Jennings MP, Oggioni MR. Manso AS, et al. Among authors: shewell lk. Nat Commun. 2014 Sep 30;5:5055. doi: 10.1038/ncomms6055. Nat Commun. 2014. PMID: 25268848 Free PMC article.
The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.
Shewell LK, Harvey RM, Higgins MA, Day CJ, Hartley-Tassell LE, Chen AY, Gillen CM, James DB, Alonzo F 3rd, Torres VJ, Walker MJ, Paton AW, Paton JC, Jennings MP. Shewell LK, et al. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5312-20. doi: 10.1073/pnas.1412703111. Epub 2014 Nov 24. Proc Natl Acad Sci U S A. 2014. PMID: 25422425 Free PMC article.
Structure aided design of a Neu5Gc specific lectin.
Day CJ, Paton AW, Higgins MA, Shewell LK, Jen FE, Schulz BL, Herdman BP, Paton JC, Jennings MP. Day CJ, et al. Among authors: shewell lk. Sci Rep. 2017 May 4;7(1):1495. doi: 10.1038/s41598-017-01522-9. Sci Rep. 2017. PMID: 28473713 Free PMC article.
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