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Genetic and pharmacological inactivation of the purinergic P2RX7 receptor dampens inflammation but increases tumor incidence in a mouse model of colitis-associated cancer.
Hofman P, Cherfils-Vicini J, Bazin M, Ilie M, Juhel T, Hébuterne X, Gilson E, Schmid-Alliana A, Boyer O, Adriouch S, Vouret-Craviari V. Hofman P, et al. Among authors: juhel t. Cancer Res. 2015 Mar 1;75(5):835-45. doi: 10.1158/0008-5472.CAN-14-1778. Epub 2015 Jan 6. Cancer Res. 2015. PMID: 25564520
P2RX7B is a new theranostic marker for lung adenocarcinoma patients.
Benzaquen J, Dit Hreich SJ, Heeke S, Juhel T, Lalvee S, Bauwens S, Saccani S, Lenormand P, Hofman V, Butori M, Leroy S, Berthet JP, Marquette CH, Hofman P, Vouret-Craviari V. Benzaquen J, et al. Among authors: juhel t. Theranostics. 2020 Aug 29;10(24):10849-10860. doi: 10.7150/thno.48229. eCollection 2020. Theranostics. 2020. PMID: 33042257 Free PMC article.
A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy.
Douguet L, Janho Dit Hreich S, Benzaquen J, Seguin L, Juhel T, Dezitter X, Duranton C, Ryffel B, Kanellopoulos J, Delarasse C, Renault N, Furman C, Homerin G, Féral C, Cherfils-Vicini J, Millet R, Adriouch S, Ghinet A, Hofman P, Vouret-Craviari V. Douguet L, et al. Among authors: juhel t. Nat Commun. 2021 Jan 28;12(1):653. doi: 10.1038/s41467-021-20912-2. Nat Commun. 2021. PMID: 33510147 Free PMC article.
Glial cell line-derived neurotrophic factor-stimulated phosphatidylinositol 3-kinase and Akt activities exert opposing effects on the ERK pathway: importance for the rescue of neuroectodermic cells.
Mograbi B, Bocciardi R, Bourget I, Busca R, Rochet N, Farahi-Far D, Juhel T, Rossi B. Mograbi B, et al. Among authors: juhel t. J Biol Chem. 2001 Nov 30;276(48):45307-19. doi: 10.1074/jbc.M101220200. Epub 2001 Sep 4. J Biol Chem. 2001. PMID: 11535584 Free article.
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