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[1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes.
Murthy S, Nizi MG, Maksimainen MM, Massari S, Alaviuhkola J, Lippok BE, Vagaggini C, Sowa ST, Galera-Prat A, Ashok Y, Venkannagari H, Prunskaite-Hyyryläinen R, Dreassi E, Lüscher B, Korn P, Tabarrini O, Lehtiö L. Murthy S, et al. Among authors: prunskaite hyyrylainen r. J Med Chem. 2023 Jan 26;66(2):1301-1320. doi: 10.1021/acs.jmedchem.2c01460. Epub 2023 Jan 4. J Med Chem. 2023. PMID: 36598465 Free PMC article.
Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15.
Nizi MG, Maksimainen MM, Murthy S, Massari S, Alaviuhkola J, Lippok BE, Sowa ST, Galera-Prat A, Prunskaite-Hyyryläinen R, Lüscher B, Korn P, Lehtiö L, Tabarrini O. Nizi MG, et al. Among authors: prunskaite hyyrylainen r. Eur J Med Chem. 2022 Jul 5;237:114362. doi: 10.1016/j.ejmech.2022.114362. Epub 2022 Apr 19. Eur J Med Chem. 2022. PMID: 35500474
Calcium signaling induces partial EMT and renal fibrosis in a Wnt4mCherry knock-in mouse model.
Naillat F, Deshar G, Hankkila A, Rak-Raszewska A, Sharma A, Prunskaite-Hyyrylainen R, Railo A, Shan J, Vainio SJ. Naillat F, et al. Among authors: prunskaite hyyrylainen r. Biochim Biophys Acta Mol Basis Dis. 2024 Jun;1870(5):167180. doi: 10.1016/j.bbadis.2024.167180. Epub 2024 Apr 21. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38653356 Free article.
Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning.
Pietilä I, Prunskaite-Hyyryläinen R, Kaisto S, Tika E, van Eerde AM, Salo AM, Garma L, Miinalainen I, Feitz WF, Bongers EM, Juffer A, Knoers NV, Renkema KY, Myllyharju J, Vainio SJ. Pietilä I, et al. PLoS One. 2016 Jan 21;11(1):e0147171. doi: 10.1371/journal.pone.0147171. eCollection 2016. PLoS One. 2016. PMID: 26794322 Free PMC article.
23 results