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[1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes.
Murthy S, Nizi MG, Maksimainen MM, Massari S, Alaviuhkola J, Lippok BE, Vagaggini C, Sowa ST, Galera-Prat A, Ashok Y, Venkannagari H, Prunskaite-Hyyryläinen R, Dreassi E, Lüscher B, Korn P, Tabarrini O, Lehtiö L. Murthy S, et al. Among authors: lehtio l. J Med Chem. 2023 Jan 26;66(2):1301-1320. doi: 10.1021/acs.jmedchem.2c01460. Epub 2023 Jan 4. J Med Chem. 2023. PMID: 36598465 Free PMC article.
Comparative structural analysis of lipid binding START domains.
Thorsell AG, Lee WH, Persson C, Siponen MI, Nilsson M, Busam RD, Kotenyova T, Schüler H, Lehtiö L. Thorsell AG, et al. Among authors: lehtio l. PLoS One. 2011;6(6):e19521. doi: 10.1371/journal.pone.0019521. Epub 2011 Jun 30. PLoS One. 2011. PMID: 21738568 Free PMC article.
Structure of Escherichia coli pyruvate formate-lyase with pyruvate.
Lehtiö L, Leppänen VM, Kozarich JW, Goldman A. Lehtiö L, et al. Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):2209-12. doi: 10.1107/s0907444902016402. Epub 2002 Nov 23. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 12454503
Substrate specificity and oligomerization of human GMP synthetase.
Welin M, Lehtiö L, Johansson A, Flodin S, Nyman T, Trésaugues L, Hammarström M, Gräslund S, Nordlund P. Welin M, et al. Among authors: lehtio l. J Mol Biol. 2013 Nov 15;425(22):4323-33. doi: 10.1016/j.jmb.2013.06.032. Epub 2013 Jun 28. J Mol Biol. 2013. PMID: 23816837 Free article.
Buried charged surface in proteins.
Kajander T, Kahn PC, Passila SH, Cohen DC, Lehtiö L, Adolfsen W, Warwicker J, Schell U, Goldman A. Kajander T, et al. Among authors: lehtio l. Structure. 2000 Nov 15;8(11):1203-14. doi: 10.1016/s0969-2126(00)00520-7. Structure. 2000. PMID: 11080642 Free article.
99 results