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High-Dose Intermittent Treatment with the Multikinase Inhibitor Sunitinib Leads to High Intra-Tumor Drug Exposure in Patients with Advanced Solid Tumors.
Gerritse SL, Labots M, Ter Heine R, Dekker H, Poel D, Tauriello DVF, Nagtegaal ID, Van Den Hombergh E, Van Erp N, Verheul HMW. Gerritse SL, et al. Among authors: van den hombergh e. Cancers (Basel). 2022 Dec 9;14(24):6061. doi: 10.3390/cancers14246061. Cancers (Basel). 2022. PMID: 36551546 Free PMC article.
Determination of protein-unbound, active rifampicin in serum by ultrafiltration and Ultra Performance Liquid Chromatography with UV detection. A method suitable for standard and high doses of rifampicin.
van Ewijk-Beneken Kolmer EWJ, Teulen MJA, van den Hombergh ECA, van Erp NE, Te Brake LHM, Aarnoutse RE. van Ewijk-Beneken Kolmer EWJ, et al. Among authors: van den hombergh eca. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 15;1063:42-49. doi: 10.1016/j.jchromb.2017.08.004. Epub 2017 Aug 4. J Chromatogr B Analyt Technol Biomed Life Sci. 2017. PMID: 28843937 Free article.
Manual punch versus automated flow-through sample desorption for dried blood spot LC-MS/MS analysis of voriconazole.
Martial LC, van den Hombergh E, Tump C, Halmingh O, Burger DM, van Maarseveen EM, Brüggemann RJ, Aarnoutse RE. Martial LC, et al. Among authors: van den hombergh e. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jul 1;1089:16-23. doi: 10.1016/j.jchromb.2018.04.039. Epub 2018 Apr 27. J Chromatogr B Analyt Technol Biomed Life Sci. 2018. PMID: 29747155
Clofazimine as a substitute for rifampicin improves efficacy of Mycobacterium avium pulmonary disease treatment in the hollow-fiber model.
Salillas S, Raaijmakers J, Aarnoutse RE, Svensson EM, Asouit K, van den Hombergh E, Te Brake L, Stemkens R, Wertheim HFL, Hoefsloot W, van Ingen J. Salillas S, et al. Among authors: van den hombergh e. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0115723. doi: 10.1128/aac.01157-23. Epub 2024 Jan 23. Antimicrob Agents Chemother. 2024. PMID: 38259101 Free PMC article.
Standard therapy of Mycobacterium avium complex pulmonary disease shows limited efficacy in an open source hollow fibre system that simulates human plasma and epithelial lining fluid pharmacokinetics.
Ruth MM, Raaijmakers J, van den Hombergh E, Aarnoutse R, Svensson EM, Susanto BO, Simonsson USH, Wertheim H, Hoefsloot W, van Ingen J. Ruth MM, et al. Among authors: van den hombergh e. Clin Microbiol Infect. 2022 Mar;28(3):448.e1-448.e7. doi: 10.1016/j.cmi.2021.07.015. Epub 2021 Jul 28. Clin Microbiol Infect. 2022. PMID: 34332109 Free article.