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Clotrimazole presents anticancer properties against a mouse melanoma model acting as a PI3K inhibitor and inducing repolarization of tumor-associated macrophages.
Ochioni AC, Imbroisi Filho R, Esteves AM, Leandro JGB, Demaria TM, do Nascimento Júnior JX, Pereira-Dutra FS, Bozza PT, Sola-Penna M, Zancan P. Ochioni AC, et al. Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1;1867(12):166263. doi: 10.1016/j.bbadis.2021.166263. Epub 2021 Sep 2. Biochim Biophys Acta Mol Basis Dis. 2021. PMID: 34481868 Free article.
Acetylsalicylic acid and salicylic acid present anticancer properties against melanoma by promoting nitric oxide-dependent endoplasmic reticulum stress and apoptosis.
Ausina P, Branco JR, Demaria TM, Esteves AM, Leandro JGB, Ochioni AC, Mendonça APM, Palhano FL, Oliveira MF, Abou-Kheir W, Sola-Penna M, Zancan P. Ausina P, et al. Among authors: ochioni ac. Sci Rep. 2020 Nov 12;10(1):19617. doi: 10.1038/s41598-020-76824-6. Sci Rep. 2020. PMID: 33184378 Free PMC article.
Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively.
Sola-Penna M, Paixão LP, Branco JR, Ochioni AC, Albanese JM, Mundim DM, Baptista-de-Souza D, Figueiredo CP, Coelho WS, Marcondes MC, Zancan P. Sola-Penna M, et al. Among authors: ochioni ac. Br J Cancer. 2020 Jan;122(2):194-208. doi: 10.1038/s41416-019-0640-1. Epub 2019 Dec 10. Br J Cancer. 2020. PMID: 31819176 Free PMC article.
Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity.
da Fonseca ACP, Ochioni AC, Martins RDS, Zembrzuski VM, Campos Junior M, Ramos VG, Carneiro JRI, Nogueira Neto JF, Cabello PH, Cabello GMK. da Fonseca ACP, et al. Among authors: ochioni ac. Dis Markers. 2017;2017:5289120. doi: 10.1155/2017/5289120. Epub 2017 Aug 29. Dis Markers. 2017. PMID: 28947843 Free PMC article.