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Page 1
Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease.
Brendza R, Gao X, Stark KL, Lin H, Lee SH, Hu C, Cai H, DiCara D, Hsiao YC, Ngu H, Foreman O, Baca M, Dohse M, Fortin JP, Corpuz R, Seshasayee D, Easton A, Ayalon G, Hötzel I, Chih B. Brendza R, et al. Neurobiol Dis. 2023 Feb;177:105969. doi: 10.1016/j.nbd.2022.105969. Epub 2022 Dec 17. Neurobiol Dis. 2023. PMID: 36535551 Free article.
Genetic ablation of Gpnmb does not alter synuclein-related pathology.
Brendza R, Lin H, Stark K, Foreman O, Tao J, Pierce A, Ngu H, Shen K, Easton AE, Bhangale T, Chang D, Bingol B, Friedman BA. Brendza R, et al. Neurobiol Dis. 2021 Nov;159:105494. doi: 10.1016/j.nbd.2021.105494. Epub 2021 Aug 28. Neurobiol Dis. 2021. PMID: 34464706 Free article.
Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease.
Ayalon G, Lee SH, Adolfsson O, Foo-Atkins C, Atwal JK, Blendstrup M, Booler H, Bravo J, Brendza R, Brunstein F, Chan R, Chandra P, Couch JA, Datwani A, Demeule B, DiCara D, Erickson R, Ernst JA, Foreman O, He D, Hötzel I, Keeley M, Kwok MCM, Lafrance-Vanasse J, Lin H, Lu Y, Luk W, Manser P, Muhs A, Ngu H, Pfeifer A, Pihlgren M, Rao GK, Scearce-Levie K, Schauer SP, Smith WB, Solanoy H, Teng E, Wildsmith KR, Bumbaca Yadav D, Ying Y, Fuji RN, Kerchner GA. Ayalon G, et al. Among authors: brendza r. Sci Transl Med. 2021 May 12;13(593):eabb2639. doi: 10.1126/scitranslmed.abb2639. Sci Transl Med. 2021. PMID: 33980574 Clinical Trial.
Ocular phenotypes in a mouse model of impaired glucocerebrosidase activity.
Weber M, Min SW, Truong T, Hung J, Dale S, Reichelt M, Ubhayakar S, Cain-Hom C, Baca M, Jiang Z, Li Q, Brendza R, Lin H, Kung C, Forrest WF, Quiason-Huynh C, Sandoval W, Chen B, Deng Y, Easton A, Foreman O, Sene A, Bingol B. Weber M, et al. Among authors: brendza r. Sci Rep. 2021 Mar 16;11(1):6079. doi: 10.1038/s41598-021-85528-4. Sci Rep. 2021. PMID: 33727605 Free PMC article.
Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS.
Dominguez S, Varfolomeev E, Brendza R, Stark K, Tea J, Imperio J, Ngu H, Earr T, Foreman O, Webster JD, Easton A, Vucic D, Bingol B. Dominguez S, et al. Among authors: brendza r. Cell Death Differ. 2021 Mar;28(3):915-931. doi: 10.1038/s41418-020-00625-7. Epub 2020 Sep 29. Cell Death Differ. 2021. PMID: 32994544 Free PMC article.
Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.
Lee SH, Le Pichon CE, Adolfsson O, Gafner V, Pihlgren M, Lin H, Solanoy H, Brendza R, Ngu H, Foreman O, Chan R, Ernst JA, DiCara D, Hotzel I, Srinivasan K, Hansen DV, Atwal J, Lu Y, Bumbaca D, Pfeifer A, Watts RJ, Muhs A, Scearce-Levie K, Ayalon G. Lee SH, et al. Among authors: brendza r. Cell Rep. 2016 Aug 9;16(6):1690-1700. doi: 10.1016/j.celrep.2016.06.099. Epub 2016 Jul 28. Cell Rep. 2016. PMID: 27475227 Free article.
Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition.
Han BH, Zhou ML, Abousaleh F, Brendza RP, Dietrich HH, Koenigsknecht-Talboo J, Cirrito JR, Milner E, Holtzman DM, Zipfel GJ. Han BH, et al. Among authors: brendza rp. J Neurosci. 2008 Dec 10;28(50):13542-50. doi: 10.1523/JNEUROSCI.4686-08.2008. J Neurosci. 2008. PMID: 19074028 Free PMC article.
Amyloid-beta immunotherapies in mice and men.
Brendza RP, Holtzman DM. Brendza RP, et al. Alzheimer Dis Assoc Disord. 2006 Apr-Jun;20(2):118-23. doi: 10.1097/01.wad.0000213810.89681.a5. Alzheimer Dis Assoc Disord. 2006. PMID: 16772748 Review.
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