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Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase.
Schaible AM, Filosa R, Temml V, Krauth V, Matteis M, Peduto A, Bruno F, Luderer S, Roviezzo F, Di Mola A, de Rosa M, D'Agostino B, Weinigel C, Barz D, Koeberle A, Pergola C, Schuster D, Werz O. Schaible AM, et al. Among authors: schuster d, d agostino b. Br J Pharmacol. 2014 May;171(9):2399-412. doi: 10.1111/bph.12592. Br J Pharmacol. 2014. PMID: 24467325 Free PMC article.
Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.
Garscha U, Romp E, Pace S, Rossi A, Temml V, Schuster D, König S, Gerstmeier J, Liening S, Werner M, Atze H, Wittmann S, Weinigel C, Rummler S, Scriba GK, Sautebin L, Werz O. Garscha U, et al. Among authors: schuster d. Sci Rep. 2017 Aug 24;7(1):9398. doi: 10.1038/s41598-017-09795-w. Sci Rep. 2017. PMID: 28839250 Free PMC article.
Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-κB/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase.
Hošek J, Leláková V, Bobál P, Pížová H, Gazdová M, Malaník M, Jakubczyk K, Veselý O, Landa P, Temml V, Schuster D, Prachyawarakorn V, Pailee P, Ren G, Zpurný F, Oravec M, Šmejkal K. Hošek J, et al. Among authors: schuster d. J Nat Prod. 2019 Jul 26;82(7):1839-1848. doi: 10.1021/acs.jnatprod.9b00081. Epub 2019 Jul 3. J Nat Prod. 2019. PMID: 31268709
Dual Inhibitory Action of a Novel AKR1C3 Inhibitor on Both Full-Length AR and the Variant AR-V7 in Enzalutamide Resistant Metastatic Castration Resistant Prostate Cancer.
Kafka M, Mayr F, Temml V, Möller G, Adamski J, Höfer J, Schwaiger S, Heidegger I, Matuszczak B, Schuster D, Klocker H, Bektic J, Stuppner H, Eder IE. Kafka M, et al. Among authors: schuster d. Cancers (Basel). 2020 Jul 28;12(8):2092. doi: 10.3390/cancers12082092. Cancers (Basel). 2020. PMID: 32731472 Free PMC article.
Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction.
Mayr F, Möller G, Garscha U, Fischer J, Rodríguez Castaño P, Inderbinen SG, Temml V, Waltenberger B, Schwaiger S, Hartmann RW, Gege C, Martens S, Odermatt A, Pandey AV, Werz O, Adamski J, Stuppner H, Schuster D. Mayr F, et al. Among authors: schuster d. Int J Mol Sci. 2020 Sep 26;21(19):7102. doi: 10.3390/ijms21197102. Int J Mol Sci. 2020. PMID: 32993084 Free PMC article.
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.
Neukirch K, Alsabil K, Dinh CP, Bilancia R, Raasch M, Ville A, Cerqua I, Viault G, Bréard D, Pace S, Temml V, Brunner E, Jordan PM, Marques MC, Loeser K, Gollowitzer A, Permann S, Gerstmeier J, Lorkowski S, Stuppner H, Garscha U, Rodrigues T, Bernardes GJL, Schuster D, Séraphin D, Richomme P, Rossi A, Mosig AS, Roviezzo F, Werz O, Helesbeux JJ, Koeberle A. Neukirch K, et al. Among authors: schuster d. J Med Chem. 2021 Aug 12;64(15):11496-11526. doi: 10.1021/acs.jmedchem.1c00806. Epub 2021 Jul 19. J Med Chem. 2021. PMID: 34279935 Free PMC article.
Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3.
Möller G, Temml V, Cala Peralta A, Gruet O, Richomme P, Séraphin D, Viault G, Kraus L, Huber-Cantonati P, Schopfhauser E, Pachmayr J, Tokarz J, Schuster D, Helesbeux JJ, Dyar KA. Möller G, et al. Among authors: schuster d. Metabolites. 2022 Jan 21;12(2):99. doi: 10.3390/metabo12020099. Metabolites. 2022. PMID: 35208174 Free PMC article.
893 results