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Pharmacokinetic boosting to enable a once-daily reduced dose of tofacitinib in patients with rheumatoid arthritis and psoriatic arthritis (the PRACTICAL study).
van der Togt CJT, Verhoef LM, van den Bemt BJF, den Broeder N, Ter Heine R, den Broeder AA. van der Togt CJT, et al. Among authors: ter heine r. Ther Adv Musculoskelet Dis. 2022 Dec 12;14:1759720X221142277. doi: 10.1177/1759720X221142277. eCollection 2022. Ther Adv Musculoskelet Dis. 2022. PMID: 36533097 Free PMC article.
Bench to bedside development of GMP grade Rhenium-188-HEDP, a radiopharmaceutical for targeted treatment of painful bone metastases.
ter Heine R, Lange R, Breukels OB, Bloemendal HJ, Rummenie RG, Wakker AM, de Graaf H, Beekman FJ, van der Westerlaken MM, Malingré MM, Wielders JP, van den Berg L, Hendrikse NH, de Klerk JM. ter Heine R, et al. Int J Pharm. 2014 Apr 25;465(1-2):317-24. doi: 10.1016/j.ijpharm.2014.01.034. Epub 2014 Feb 19. Int J Pharm. 2014. PMID: 24560635
Quantification of the HIV-integrase inhibitor raltegravir and detection of its main metabolite in human plasma, dried blood spots and peripheral blood mononuclear cell lysate by means of high-performance liquid chromatography tandem mass spectrometry.
Ter Heine R, Hillebrand MJ, Rosing H, van Gorp EC, Mulder JW, Beijnen JH, Huitema AD. Ter Heine R, et al. J Pharm Biomed Anal. 2009 Feb 20;49(2):451-8. doi: 10.1016/j.jpba.2008.11.025. Epub 2008 Nov 27. J Pharm Biomed Anal. 2009. PMID: 19128911
Treatment of painful bone metastases in prostate and breast cancer patients with the therapeutic radiopharmaceutical rhenium-188-HEDP. Clinical benefit in a real-world study.
Lange R, Overbeek F, de Klerk JM, Pasker-de Jong PC, van den Berk AM, Ter Heine R, Rodenburg CJ, Kooistra A, Hendrikse NH, Bloemendal HJ. Lange R, et al. Among authors: ter heine r. Nuklearmedizin. 2016 Sep 26;55(5):188-95. doi: 10.3413/Nukmed-0828-16-05. Epub 2016 Jul 22. Nuklearmedizin. 2016. PMID: 27443809 Clinical Trial.
Drug composition matters: the influence of carrier concentration on the radiochemical purity, hydroxyapatite affinity and in-vivo bone accumulation of the therapeutic radiopharmaceutical 188Rhenium-HEDP.
Lange R, de Klerk JMH, Bloemendal HJ, Ramakers RM, Beekman FJ, van der Westerlaken MML, Hendrikse NH, Ter Heine R. Lange R, et al. Among authors: ter heine r. Nucl Med Biol. 2015 May;42(5):465-469. doi: 10.1016/j.nucmedbio.2015.01.007. Epub 2015 Jan 22. Nucl Med Biol. 2015. PMID: 25662844
162 results