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The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity.
Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Nowak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C, Knolle PA. Klotz L, et al. J Exp Med. 2009 Sep 28;206(10):2079-89. doi: 10.1084/jem.20082771. Epub 2009 Sep 8. J Exp Med. 2009. PMID: 19737866 Free PMC article.
Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor γ.
Hucke S, Floßdorf J, Grützke B, Dunay IR, Frenzel K, Jungverdorben J, Linnartz B, Mack M, Peitz M, Brüstle O, Kurts C, Klockgether T, Neumann H, Prinz M, Wiendl H, Knolle P, Klotz L. Hucke S, et al. Among authors: klotz l. Brain. 2012 May;135(Pt 5):1586-605. doi: 10.1093/brain/aws058. Epub 2012 Mar 24. Brain. 2012. PMID: 22447120
Salt-dependent chemotaxis of macrophages.
Müller S, Quast T, Schröder A, Hucke S, Klotz L, Jantsch J, Gerzer R, Hemmersbach R, Kolanus W. Müller S, et al. Among authors: klotz l. PLoS One. 2013 Sep 16;8(9):e73439. doi: 10.1371/journal.pone.0073439. eCollection 2013. PLoS One. 2013. PMID: 24066047 Free PMC article.
Fingolimod treatment promotes regulatory phenotype and function of B cells.
Grützke B, Hucke S, Gross CC, Herold MV, Posevitz-Fejfar A, Wildemann BT, Kieseier BC, Dehmel T, Wiendl H, Klotz L. Grützke B, et al. Among authors: klotz l. Ann Clin Transl Neurol. 2015 Feb;2(2):119-30. doi: 10.1002/acn3.155. Epub 2015 Jan 16. Ann Clin Transl Neurol. 2015. PMID: 25750917 Free PMC article.
1,048 results