Yang SY - Search Results

1

Tumor PKCδ instigates immune exclusion in EGFR-mutated non-small cell lung cancer.

Zuo YH, Gao WN, Xie YJ, Yang SY, Zhou JT, Liang HH, Fan XX. Zuo YH, et al. Among authors: yang sy. BMC Med. 2022 Dec 8;20(1):470. doi: 10.1186/s12916-022-02670-0. BMC Med. 2022. PMID: 36482371 Free PMC article.

2

Preclinical pharmacodynamic evaluation of drug candidate SKLB-178 in the treatment of non-small cell lung cancer.

Zhong L, Yang J, Cao Z, Chen X, Hu Y, Li L, Yang S. Zhong L, et al. Oncotarget. 2017 Feb 21;8(8):12843-12854. doi: 10.18632/oncotarget.14597. Oncotarget. 2017. PMID: 28086226 Free PMC article.

3

Novel ROR1 inhibitor ARI-1 suppresses the development of non-small cell lung cancer.

Liu X, Pu W, He H, Fan X, Zheng Y, Zhou JK, Ma R, He J, Zheng Y, Wu K, Zhao Y, Yang SY, Wang C, Wei YQ, Wei XW, Peng Y. Liu X, et al. Among authors: yang sy. Cancer Lett. 2019 Aug 28;458:76-85. doi: 10.1016/j.canlet.2019.05.016. Epub 2019 May 21. Cancer Lett. 2019. PMID: 31125641

4

Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.

Wang X, Yu C, Wang C, Ma Y, Wang T, Li Y, Huang Z, Zhou M, Sun P, Zheng J, Yang S, Fan Y, Xiang R. Wang X, et al. Eur J Med Chem. 2019 Nov 1;181:111535. doi: 10.1016/j.ejmech.2019.07.038. Epub 2019 Jul 25. Eur J Med Chem. 2019. PMID: 31376566

5

Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment.

Wang C, Wang X, Huang Z, Wang T, Nie Y, Yang S, Xiang R, Fan Y. Wang C, et al. Eur J Med Chem. 2022 Jul 5;237:114381. doi: 10.1016/j.ejmech.2022.114381. Epub 2022 Apr 15. Eur J Med Chem. 2022. PMID: 35447433

6

SKLB610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo.

Cao ZX, Zheng RL, Lin HJ, Luo SD, Zhou Y, Xu YZ, Zeng XX, Wang Z, Zhou LN, Mao YQ, Yang L, Wei YQ, Yu LT, Yang SY, Zhao YL. Cao ZX, et al. Among authors: yang sy, yang l. Cell Physiol Biochem. 2011;27(5):565-74. doi: 10.1159/000329978. Epub 2011 Jun 15. Cell Physiol Biochem. 2011. PMID: 21691074 Free article.

7

Systems biology modeling reveals a possible mechanism of the tumor cell death upon oncogene inactivation in EGFR addicted cancers.

Zhou JP, Chen X, Feng S, Luo SD, Pan YL, Zhong L, Ji P, Wang ZR, Ma S, Li LL, Wei YQ, Yang SY. Zhou JP, et al. Among authors: yang sy. PLoS One. 2011;6(12):e28930. doi: 10.1371/journal.pone.0028930. Epub 2011 Dec 14. PLoS One. 2011. PMID: 22194952 Free PMC article.

8

SKLB1206, a novel orally available multikinase inhibitor targeting EGFR activating and T790M mutants, ErbB2, ErbB4, and VEGFR2, displays potent antitumor activity both in vitro and in vivo.

Pan Y, Xu Y, Feng S, Luo S, Zheng R, Yang J, Wang L, Zhong L, Yang HY, Wang BL, Yu Y, Liu J, Cao Z, Wang X, Ji P, Wang Z, Chen X, Zhang S, Wei YQ, Yang SY. Pan Y, et al. Among authors: yang sy, yang hy, yang j. Mol Cancer Ther. 2012 Apr;11(4):952-62. doi: 10.1158/1535-7163.MCT-11-0679. Epub 2012 Feb 8. Mol Cancer Ther. 2012. PMID: 22319204

9

Structural optimization and structure-activity relationships of N2-(4-(4-Methylpiperazin-1-yl)phenyl)-N8-phenyl-9H-purine-2,8-diamine derivatives, a new class of reversible kinase inhibitors targeting both EGFR-activating and resistance mutations.

Yang J, Wang LJ, Liu JJ, Zhong L, Zheng RL, Xu Y, Ji P, Zhang CH, Wang WJ, Lin XD, Li LL, Wei YQ, Yang SY. Yang J, et al. Among authors: yang sy. J Med Chem. 2012 Dec 13;55(23):10685-99. doi: 10.1021/jm301365e. Epub 2012 Nov 16. J Med Chem. 2012. PMID: 23116168

10

A preclinical evaluation of SKLB261, a multikinase inhibitor of EGFR/Src/VEGFR2, as a therapeutic agent against pancreatic cancer.

Pan Y, Zheng M, Zhong L, Yang J, Zhou S, Qin Y, Xiang R, Chen Y, Yang SY. Pan Y, et al. Among authors: yang sy, yang j. Mol Cancer Ther. 2015 Feb;14(2):407-18. doi: 10.1158/1535-7163.MCT-14-0485. Epub 2014 Dec 17. Mol Cancer Ther. 2015. PMID: 25519702

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