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The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.
Sakai K, Ami Y, Tahara M, Kubota T, Anraku M, Abe M, Nakajima N, Sekizuka T, Shirato K, Suzaki Y, Ainai A, Nakatsu Y, Kanou K, Nakamura K, Suzuki T, Komase K, Nobusawa E, Maenaka K, Kuroda M, Hasegawa H, Kawaoka Y, Tashiro M, Takeda M. Sakai K, et al. Among authors: sekizuka t. J Virol. 2014 May;88(10):5608-16. doi: 10.1128/JVI.03677-13. Epub 2014 Mar 5. J Virol. 2014. PMID: 24600012 Free PMC article.
A mutant H3N2 influenza virus uses an alternative activation mechanism in TMPRSS2 knockout mice by loss of an oligosaccharide in the hemagglutinin stalk region.
Sakai K, Sekizuka T, Ami Y, Nakajima N, Kitazawa M, Sato Y, Nakajima K, Anraku M, Kubota T, Komase K, Takehara K, Hasegawa H, Odagiri T, Tashiro M, Kuroda M, Takeda M. Sakai K, et al. Among authors: sekizuka t. J Virol. 2015 May;89(9):5154-8. doi: 10.1128/JVI.00124-15. Epub 2015 Feb 11. J Virol. 2015. PMID: 25673722 Free PMC article.
Molecular evolution of haemagglutinin (H) gene in measles virus.
Kimura H, Saitoh M, Kobayashi M, Ishii H, Saraya T, Kurai D, Tsukagoshi H, Shirabe K, Nishina A, Kozawa K, Kuroda M, Takeuchi F, Sekizuka T, Minakami H, Ryo A, Takeda M. Kimura H, et al. Among authors: sekizuka t. Sci Rep. 2015 Jul 1;5:11648. doi: 10.1038/srep11648. Sci Rep. 2015. PMID: 26130388 Free PMC article.
218 results