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Page 1
Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling.
Luan D, Dadpey B, Zaid J, Bridge-Comer PE, DeLuca JH, Xia W, Castle J, Reilly SM. Luan D, et al. Among authors: reilly sm. Diabetes. 2023 Mar 1;72(3):367-374. doi: 10.2337/db22-0444. Diabetes. 2023. PMID: 36449000 Free PMC article.
RalA controls glucose homeostasis by regulating glucose uptake in brown fat.
Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR. Skorobogatko Y, et al. Among authors: reilly sm. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7819-7824. doi: 10.1073/pnas.1801050115. Epub 2018 Jun 18. Proc Natl Acad Sci U S A. 2018. PMID: 29915037 Free PMC article.
FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.
Reilly SM, Abu-Odeh M, Ameka M, DeLuca JH, Naber MC, Dadpey B, Ebadat N, Gomez AV, Peng X, Poirier B, Walk E, Potthoff MJ, Saltiel AR. Reilly SM, et al. J Clin Invest. 2021 May 17;131(10):e145546. doi: 10.1172/JCI145546. J Clin Invest. 2021. PMID: 33822771 Free PMC article.
Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes.
Keinan O, Valentine JM, Xiao H, Mahata SK, Reilly SM, Abu-Odeh M, Deluca JH, Dadpey B, Cho L, Pan A, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Lusis AJ, Laakso M, Chouchani ET, Rydén M, Saltiel AR. Keinan O, et al. Among authors: reilly sm. Nature. 2021 Nov;599(7884):296-301. doi: 10.1038/s41586-021-04019-8. Epub 2021 Oct 27. Nature. 2021. PMID: 34707293 Free PMC article.
Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes.
Guma M, Dadpey B, Coras R, Mikuls TR, Hamilton B, Quehenberger O, Thorisdottir H, Bittleman D, Lauro K, Reilly SM, Liu-Bryan R, Terkeltaub R. Guma M, et al. Among authors: reilly sm. Arthritis Res Ther. 2022 Jul 25;24(1):175. doi: 10.1186/s13075-022-02852-4. Arthritis Res Ther. 2022. PMID: 35879786 Free PMC article.
Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.
Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne TE, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu RT, Downes M, Evans RM, Rydén M, Wabitsch M, Wang Z, Hakozaki H, Schöneberg J, Reilly SM, Huang J, Saltiel AR. Xia W, et al. Among authors: reilly sm. Nat Metab. 2024 Feb;6(2):273-289. doi: 10.1038/s42255-024-00978-0. Epub 2024 Jan 29. Nat Metab. 2024. PMID: 38286821 Free PMC article.
Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.
Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR. Oral EA, et al. Among authors: reilly sm. Cell Metab. 2017 Jul 5;26(1):157-170.e7. doi: 10.1016/j.cmet.2017.06.006. Cell Metab. 2017. PMID: 28683283 Free PMC article. Clinical Trial.
119 results