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Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome.
Urbinati C, Lanzillotta C, Cosentino L, Valenti D, Quattrini MC, Di Crescenzo L, Prestia F, Pietraforte D, Perluigi M, Di Domenico F, Vacca RA, De Filippis B. Urbinati C, et al. Among authors: perluigi m. Neuropharmacology. 2023 Feb 15;224:109350. doi: 10.1016/j.neuropharm.2022.109350. Epub 2022 Nov 25. Neuropharmacology. 2023. PMID: 36442649
Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease.
Reed T, Perluigi M, Sultana R, Pierce WM, Klein JB, Turner DM, Coccia R, Markesbery WR, Butterfield DA. Reed T, et al. Among authors: perluigi m. Neurobiol Dis. 2008 Apr;30(1):107-20. doi: 10.1016/j.nbd.2007.12.007. Epub 2008 Jan 5. Neurobiol Dis. 2008. PMID: 18325775
145 results