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Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation.
Spanjaard A, Stratigopoulou M, de Groot D, Aslam M, van den Berk PCM, Stappenbelt C, Ayidah M, Catsman JJI, Pardieck IN, Kreft M, Arens R, Guikema JEJ, Jacobs H. Spanjaard A, et al. Among authors: van den berk pcm. Front Immunol. 2023 Jan 9;13:986863. doi: 10.3389/fimmu.2022.986863. eCollection 2022. Front Immunol. 2023. PMID: 36700204 Free PMC article.
Mammalian life depends on two distinct pathways of DNA damage tolerance.
Buoninfante OA, Pilzecker B, Spanjaard A, de Groot D, Prekovic S, Song JY, Lieftink C, Ayidah M, Pritchard CEJ, Vivié J, Mcgrath KE, Huijbers IJ, Philipsen S, von Lindern M, Zwart W, Beijersbergen RL, Palis J, van den Berk PCM, Jacobs H. Buoninfante OA, et al. Among authors: van den berk pcm. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2216055120. doi: 10.1073/pnas.2216055120. Epub 2023 Jan 20. Proc Natl Acad Sci U S A. 2023. PMID: 36669105 Free PMC article.
Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine.
Spanjaard A, Shah R, de Groot D, Buoninfante OA, Morris B, Lieftink C, Pritchard C, Zürcher LM, Ormel S, Catsman JJI, de Korte-Grimmerink R, Siteur B, Proost N, Boadum T, van de Ven M, Song JY, Kreft M, van den Berk PCM, Beijersbergen RL, Jacobs H. Spanjaard A, et al. Among authors: van den berk pcm. Nucleic Acids Res. 2022 Jul 22;50(13):7420-7435. doi: 10.1093/nar/gkac545. Nucleic Acids Res. 2022. PMID: 35819193 Free PMC article.
The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity.
Will Castro LSEP, Pieters W, Alemdehy MF, Aslam MA, Buoninfante OA, Raaijmakers JA, Pilzecker B, van den Berk PCM, Te Riele H, Medema RH, Pedrosa RC, Jacobs H. Will Castro LSEP, et al. Among authors: van den berk pcm. Front Pharmacol. 2021 Feb 18;12:596535. doi: 10.3389/fphar.2021.596535. eCollection 2021. Front Pharmacol. 2021. PMID: 33679394 Free PMC article.
USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells.
van den Berk P, Lancini C, Company C, Serresi M, Sanchez-Bailon MP, Hulsman D, Pritchard C, Song JY, Schmitt MJ, Tanger E, Popp O, Mertins P, Huijbers IJ, Jacobs H, van Lohuizen M, Gargiulo G, Citterio E. van den Berk P, et al. Cell Rep. 2020 Dec 29;33(13):108533. doi: 10.1016/j.celrep.2020.108533. Cell Rep. 2020. PMID: 33378683 Free PMC article.
The Ig heavy chain protein but not its message controls early B cell development.
Aslam MA, Alemdehy MF, Hao B, Krijger PHL, Pritchard CEJ, de Rink I, Muhaimin FI, Nurzijah I, van Baalen M, Kerkhoven RM, van den Berk PCM, Skok JA, Jacobs H. Aslam MA, et al. Among authors: van den berk pcm. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31343-31352. doi: 10.1073/pnas.2004810117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229554 Free PMC article.
269 results