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Low MBOAT7 expression, a genetic risk for MASH, promotes a pro-fibrotic pathway involving hepatocyte TAZ upregulation.
Moore MP, Wang X, Kennelly JP, Shi H, Ishino Y, Kano K, Aoki J, Cherubini A, Ronzoni L, Guo X, Chalasani NP, Khalid S, Saleheen D, Mitsche MA, Rotter JI, Yates KP, Valenti L, Kono N, Tontonoz P, Tabas I. Moore MP, et al. Among authors: tontonoz p. Hepatology. 2024 May 22. doi: 10.1097/HEP.0000000000000933. Online ahead of print. Hepatology. 2024. PMID: 38776184
Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses.
Vladimir de la Rosa J, Tabraue C, Huang Z, Orizaola MC, Martin-Rodríguez P, Steffensen KR, Zapata JM, Boscá L, Tontonoz P, Alemany S, Treuter E, Castrillo A. Vladimir de la Rosa J, et al. Among authors: tontonoz p. Adv Sci (Weinh). 2024 May;11(20):e2307201. doi: 10.1002/advs.202307201. Epub 2024 Mar 28. Adv Sci (Weinh). 2024. PMID: 38549193 Free PMC article.
Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake.
Ferrari A, Whang E, Xiao X, Kennelly JP, Romartinez-Alonso B, Mack JJ, Weston T, Chen K, Kim Y, Tol MJ, Bideyan L, Nguyen A, Gao Y, Cui L, Bedard AH, Sandhu J, Lee SD, Fairall L, Williams KJ, Song W, Munguia P, Russell RA, Martin MG, Jung ME, Jiang H, Schwabe JWR, Young SG, Tontonoz P. Ferrari A, et al. Among authors: tontonoz p. Science. 2023 Nov 10;382(6671):eadf0966. doi: 10.1126/science.adf0966. Epub 2023 Nov 10. Science. 2023. PMID: 37943936 Free PMC article.
The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing.
Song W, Beigneux AP, Weston TA, Chen K, Yang Y, Nguyen LP, Guagliardo P, Jung H, Tran AP, Tu Y, Tran C, Birrane G, Miyashita K, Nakajima K, Murakami M, Tontonoz P, Jiang H, Ploug M, Fong LG, Young SG. Song W, et al. Among authors: tontonoz p. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2313825120. doi: 10.1073/pnas.2313825120. Epub 2023 Oct 23. Proc Natl Acad Sci U S A. 2023. PMID: 37871217 Free PMC article.
265 results