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Page 1
Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial.
Chastre J, François B, Bourgeois M, Komnos A, Ferrer R, Rahav G, De Schryver N, Lepape A, Koksal I, Luyt CE, Sánchez-García M, Torres A, Eggimann P, Koulenti D, Holland TL, Ali O, Shoemaker K, Ren P, Sauser J, Ruzin A, Tabor DE, Akhgar A, Wu Y, Jiang Y, DiGiandomenico A, Colbert S, Vandamme D, Coenjaerts F, Malhotra-Kumar S, Timbermont L, Oliver A, Barraud O, Bellamy T, Bonten M, Goossens H, Reisner C, Esser MT, Jafri HS; COMBACTE-MAGNET EVADE Study Group. Chastre J, et al. Among authors: ruzin a. Crit Care. 2022 Nov 15;26(1):355. doi: 10.1186/s13054-022-04204-9. Crit Care. 2022. PMID: 36380312 Free PMC article. Clinical Trial.
Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients.
Diaz Caballero J, Wheatley RM, Kapel N, López-Causapé C, Van der Schalk T, Quinn A, Shaw LP, Ogunlana L, Recanatini C, Xavier BB, Timbermont L, Kluytmans J, Ruzin A, Esser M, Malhotra-Kumar S, Oliver A, MacLean RC. Diaz Caballero J, et al. Among authors: ruzin a. Nat Commun. 2023 Jul 12;14(1):4083. doi: 10.1038/s41467-023-39416-2. Nat Commun. 2023. PMID: 37438338 Free PMC article.
Correction: Plasma protein biomarkers reflective of the host response in patients developing Intensive Care Unit-acquired pneumonia.
van Engelen TSR, Reijnders TDY, Paling FP, Bonten MJM, Timbermont L, Malhotra-Kumar S, Kluytmans JAJW, Peters-Sengers H, van der Poll T; ASPIRE-I. C. U. Study Team. van Engelen TSR, et al. Crit Care. 2023 Nov 1;27(1):420. doi: 10.1186/s13054-023-04700-6. Crit Care. 2023. PMID: 37915039 Free PMC article. No abstract available.
Postoperative Staphylococcus aureus Infections in Patients With and Without Preoperative Colonization.
Troeman DPR, Hazard D, Timbermont L, Malhotra-Kumar S, van Werkhoven CH, Wolkewitz M, Ruzin A, Goossens H, Bonten MJM, Harbarth S, Sifakis F, Kluytmans JAJW; ASPIRE-SSI Study Team; Vlaeminck J, Vilken T, Xavier BB, Lammens C, van Esschoten M, Paling FP, Recanatini C, Coenjaerts F, Sellman B, Tkaczyk C, Weber S, Ekkelenkamp MB, van der Laan L, Vierhout BP, Couvé-Deacon E, David M, Chadwick D, Llewelyn MJ, Ustianowski A, Bateman A, Mawer D, Carevic B, Konstantinovic S, Djordjevic Z, Del Toro-López MD, Gallego JPH, Escudero D, Rojo MP, Torre-Cisneros J, Castelli F, Nardi G, Barbadoro P, Altmets M, Mitt P, Todor A, Bubenek-Turconi SI, Corneci D, Sandesc D, Gheorghita V, Brat R, Hanke I, Neumann J, Tomáš T, Laffut W, Van den Abeele AM. Troeman DPR, et al. Among authors: ruzin a. JAMA Netw Open. 2023 Oct 2;6(10):e2339793. doi: 10.1001/jamanetworkopen.2023.39793. JAMA Netw Open. 2023. PMID: 37906196 Free PMC article.
Performance of the Cepheid Methicillin-Resistant Staphylococcus aureus/S. aureus Skin and Soft Tissue Infection PCR Assay on Respiratory Samples from Mechanically Ventilated Patients for S. aureus Screening during the Phase 2 Double-Blind SAATELLITE Study.
Ruzin A, Barraud O, Yu L, François B, Sánchez-Garcia M, Eggimann P, Dequin PF, Laterre PF, Huberlant V, Viña L, Boulain T, Bretonniere C, Pugin J, Trenado J, Hernandez Padilla AC, Vignaud J, Vandamme D, Goossens H, Lammens C, Ali SO, Shoemaker K, Ren P, Colbert S, Bellamy T, Sellman BR, McCarthy M, Jafri HS, Esser MT; SAATELLITE Study Group. Ruzin A, et al. J Clin Microbiol. 2022 Jul 20;60(7):e0034722. doi: 10.1128/jcm.00347-22. Epub 2022 Jun 27. J Clin Microbiol. 2022. PMID: 35758652 Free PMC article. Clinical Trial.
Susceptibility profiles and resistance genomics of Pseudomonas aeruginosa isolates from European ICUs participating in the ASPIRE-ICU trial.
Torrens G, van der Schalk TE, Cortes-Lara S, Timbermont L, Del Barrio-Tofiño E, Xavier BB, Zamorano L, Lammens C, Ali O, Ruzin A, Goossens H, Kumar-Singh S, Kluytmans J, Paling F, MacLean RC, Köhler T, López-Causapé C, Malhotra-Kumar S, Oliver A; ASPIRE-ICU study team. Torrens G, et al. Among authors: ruzin a. J Antimicrob Chemother. 2022 Jun 29;77(7):1862-1872. doi: 10.1093/jac/dkac122. J Antimicrob Chemother. 2022. PMID: 35451008 Clinical Trial.
Evaluation of GeneXpert PA assay compared to genomic and (semi-)quantitative culture methods for direct detection of Pseudomonas aeruginosa in endotracheal aspirates.
van der Schalk TE, Coppens J, Timbermont L, Turlej-Rogacka A, Van Heirstraeten L, Berkell M, Yu L, Lammens C, Xavier BB, Matheeussen V, Ieven M, McCarthy M, Jorens PG, Ruzin A, Esser MT, Kumar-Singh S, Goossens H, Malhotra-Kumar S. van der Schalk TE, et al. Among authors: ruzin a. Antimicrob Resist Infect Control. 2021 Jul 23;10(1):110. doi: 10.1186/s13756-021-00978-9. Antimicrob Resist Infect Control. 2021. PMID: 34301343 Free PMC article.
Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection.
Wheatley R, Diaz Caballero J, Kapel N, de Winter FHR, Jangir P, Quinn A, Del Barrio-Tofiño E, López-Causapé C, Hedge J, Torrens G, Van der Schalk T, Xavier BB, Fernández-Cuenca F, Arenzana A, Recanatini C, Timbermont L, Sifakis F, Ruzin A, Ali O, Lammens C, Goossens H, Kluytmans J, Kumar-Singh S, Oliver A, Malhotra-Kumar S, MacLean C. Wheatley R, et al. Among authors: ruzin a. Nat Commun. 2021 Apr 28;12(1):2460. doi: 10.1038/s41467-021-22814-9. Nat Commun. 2021. PMID: 33911082 Free PMC article.
52 results