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The orphan G protein-coupled receptor, GPR139, is expressed in the hypothalamus and is involved in the regulation of body mass, blood glucose, and insulin.
Nogueira PAS, Moura-Assis A, Zanesco AM, Bombassaro B, Gallo-Ferraz AL, Simões MR, Engel DF, Razolli DS, Gaspar JM, Junior JD, Velloso LA. Nogueira PAS, et al. Among authors: razolli ds. Neurosci Lett. 2023 Jan 1;792:136955. doi: 10.1016/j.neulet.2022.136955. Epub 2022 Nov 5. Neurosci Lett. 2023. PMID: 36347339
Fructose-induced hypothalamic AMPK activation stimulates hepatic PEPCK and gluconeogenesis due to increased corticosterone levels.
Kinote A, Faria JA, Roman EA, Solon C, Razolli DS, Ignacio-Souza LM, Sollon CS, Nascimento LF, de Araújo TM, Barbosa AP, Lellis-Santos C, Velloso LA, Bordin S, Anhê GF. Kinote A, et al. Among authors: razolli ds. Endocrinology. 2012 Aug;153(8):3633-45. doi: 10.1210/en.2012-1341. Epub 2012 May 14. Endocrinology. 2012. PMID: 22585831
Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats.
Faria JA, Kinote A, Ignacio-Souza LM, de Araújo TM, Razolli DS, Doneda DL, Paschoal LB, Lellis-Santos C, Bertolini GL, Velloso LA, Bordin S, Anhê GF. Faria JA, et al. Among authors: razolli ds. Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E230-42. doi: 10.1152/ajpendo.00094.2013. Epub 2013 May 21. Am J Physiol Endocrinol Metab. 2013. PMID: 23695212 Free article.
36 results