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The HUSH complex controls brain architecture and protocadherin fidelity.
Hagelkruys A, Horrer M, Taubenschmid-Stowers J, Kavirayani A, Novatchkova M, Orthofer M, Pai TP, Cikes D, Zhuk S, Balmaña M, Esk C, Koglgruber R, Moeseneder P, Lazovic J, Zopf LM, Cronin SJF, Elling U, Knoblich JA, Penninger JM. Hagelkruys A, et al. Among authors: knoblich ja. Sci Adv. 2022 Nov 4;8(44):eabo7247. doi: 10.1126/sciadv.abo7247. Epub 2022 Nov 4. Sci Adv. 2022. PMID: 36332029 Free PMC article.
A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog.
Hagelkruys A, Lagger S, Krahmer J, Leopoldi A, Artaker M, Pusch O, Zezula J, Weissmann S, Xie Y, Schöfer C, Schlederer M, Brosch G, Matthias P, Selfridge J, Lassmann H, Knoblich JA, Seiser C. Hagelkruys A, et al. Among authors: knoblich ja. Development. 2014 Feb;141(3):604-616. doi: 10.1242/dev.100487. Development. 2014. PMID: 24449838 Free PMC article.
Genetically engineered cerebral organoids model brain tumor formation.
Bian S, Repic M, Guo Z, Kavirayani A, Burkard T, Bagley JA, Krauditsch C, Knoblich JA. Bian S, et al. Among authors: knoblich ja. Nat Methods. 2018 Aug;15(8):631-639. doi: 10.1038/s41592-018-0070-7. Epub 2018 Jul 23. Nat Methods. 2018. PMID: 30038414 Free PMC article.
Amplification of human interneuron progenitors promotes brain tumors and neurological defects.
Eichmüller OL, Corsini NS, Vértesy Á, Morassut I, Scholl T, Gruber VE, Peer AM, Chu J, Novatchkova M, Hainfellner JA, Paredes MF, Feucht M, Knoblich JA. Eichmüller OL, et al. Among authors: knoblich ja. Science. 2022 Jan 28;375(6579):eabf5546. doi: 10.1126/science.abf5546. Epub 2022 Jan 28. Science. 2022. PMID: 35084981 Free PMC article.
Neutral competition explains the clonal composition of neural organoids.
Pflug FG, Haendeler S, Esk C, Lindenhofer D, Knoblich JA, von Haeseler A. Pflug FG, et al. Among authors: knoblich ja. PLoS Comput Biol. 2024 Apr 22;20(4):e1012054. doi: 10.1371/journal.pcbi.1012054. eCollection 2024 Apr. PLoS Comput Biol. 2024. PMID: 38648250 Free PMC article.
Cerebral organoids display dynamic clonal growth and tunable tissue replenishment.
Lindenhofer D, Haendeler S, Esk C, Littleboy JB, Brunet Avalos C, Naas J, Pflug FG, van de Ven EGP, Reumann D, Baffet AD, von Haeseler A, Knoblich JA. Lindenhofer D, et al. Among authors: knoblich ja. Nat Cell Biol. 2024 May;26(5):710-718. doi: 10.1038/s41556-024-01412-z. Epub 2024 May 7. Nat Cell Biol. 2024. PMID: 38714853 Free PMC article.
154 results