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Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron.
Chen DY, Kenney D, Chin CV, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Chen DY, et al. bioRxiv [Preprint]. 2023 Jan 10:2022.10.13.512134. doi: 10.1101/2022.10.13.512134. bioRxiv. 2023. PMID: 36263066 Free PMC article. Preprint.
SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway.
Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M. Chen DY, et al. Among authors: chen cs. bioRxiv [Preprint]. 2020 Oct 28:2020.10.27.358259. doi: 10.1101/2020.10.27.358259. bioRxiv. 2020. PMID: 33140044 Free PMC article. Preprint.
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation.
Chen DY, Chin CV, Kenney D, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Adams S, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M. Chen DY, et al. Nature. 2023 Mar;615(7950):143-150. doi: 10.1038/s41586-023-05697-2. Epub 2023 Jan 11. Nature. 2023. PMID: 36630998
IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity.
Ejemel M, Li Q, Hou S, Schiller ZA, Wallace AL, Amcheslavsky A, Yilmaz NK, Toomey JR, Schneider R, Close BJ, Chen DY, Conway HL, Mohsan S, Cavacini LA, Klempner MS, Schiffer CA, Wang Y. Ejemel M, et al. Among authors: chen dy. bioRxiv [Preprint]. 2020 May 15:2020.05.15.096719. doi: 10.1101/2020.05.15.096719. bioRxiv. 2020. PMID: 32511396 Free PMC article. Updated. Preprint.
SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs.
Weingarten-Gabbay S, Klaeger S, Sarkizova S, Pearlman LR, Chen DY, Bauer MR, Taylor HB, Conway HL, Tomkins-Tinch CH, Finkel Y, Nachshon A, Gentili M, Rivera KD, Keskin DB, Rice CM, Clauser KR, Hacohen N, Carr SA, Abelin JG, Saeed M, Sabeti PC. Weingarten-Gabbay S, et al. Among authors: chen dy. bioRxiv [Preprint]. 2020 Oct 26:2020.10.02.324145. doi: 10.1101/2020.10.02.324145. bioRxiv. 2020. PMID: 33024965 Free PMC article. Preprint.
SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway.
Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Fuchs SY, Connor JH, Douam F, Emili A, Saeed M. Chen DY, et al. Among authors: chen cs. J Virol. 2021 Sep 9;95(19):e0086221. doi: 10.1128/JVI.00862-21. Epub 2021 Sep 9. J Virol. 2021. PMID: 34260266 Free PMC article.
High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.
Datta S, Chen DY, Tavares AH, Reyes-Robles T, Ryu KA, Khan N, Bechtel TJ, Bertoch JM, White CH, Hazuda DJ, Vora KA, Hett EC, Fadeyi OO, Oslund RC, Emili A, Saeed M. Datta S, et al. Among authors: chen dy. Cell Chem Biol. 2023 Oct 19;30(10):1313-1322.e7. doi: 10.1016/j.chembiol.2023.06.028. Epub 2023 Jul 26. Cell Chem Biol. 2023. PMID: 37499664
The HLA-II immunopeptidome of SARS-CoV-2.
Weingarten-Gabbay S, Chen DY, Sarkizova S, Taylor HB, Gentili M, Pearlman LR, Bauer MR, Rice CM, Clauser KR, Hacohen N, Carr SA, Abelin JG, Saeed M, Sabeti PC. Weingarten-Gabbay S, et al. Among authors: chen dy. bioRxiv [Preprint]. 2023 Jun 1:2023.05.26.542482. doi: 10.1101/2023.05.26.542482. bioRxiv. 2023. PMID: 37398281 Free PMC article. Updated. Preprint.
1,430 results